Source:http://linkedlifedata.com/resource/pubmed/id/17189665
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2007-5-15
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pubmed:abstractText |
Nine new 2-(substituted phenyl)/alkyl[1,3,4]thiadiazolo[2,3-b]-6,7,8,9-tetrahydrobenzo(b)thieno[3,2-e]pyrimidin-5(4H)-ones, six new 3-amino-2-[(2-oxo-2-(aryl)ethyl)thio]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-ones, one 2-mercapto[1,3,4]thiadiazolo[2,3-b]-6,7,8,9-tetrahydrobenzo(b)thieno[3,2-e]pyrimidin-5(4H)-one and one 2-chloromethyl[1,3,4]thiadiazolo[2,3-b]-6,7,8,9-tetrahydrobenzo(b)thieno[3,2-e]pyrimidin-5(4H)-one were synthesized from 3-amino-2-mercapto-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one. The newly synthesized compounds were characterized by analytical and spectral data. Compounds were screened for anti-inflammatory, CNS depressant and antimicrobial activities. Some of the compounds exhibited promising biological activities.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0223-5234
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
719-28
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pubmed:meshHeading |
pubmed-meshheading:17189665-Animals,
pubmed-meshheading:17189665-Anti-Bacterial Agents,
pubmed-meshheading:17189665-Antifungal Agents,
pubmed-meshheading:17189665-Female,
pubmed-meshheading:17189665-Male,
pubmed-meshheading:17189665-Pyrimidinones,
pubmed-meshheading:17189665-Rats,
pubmed-meshheading:17189665-Rats, Wistar,
pubmed-meshheading:17189665-Spectrophotometry, Infrared
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pubmed:year |
2007
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pubmed:articleTitle |
Synthesis of some new bioactive 3-amino-2-mercapto-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one derivatives.
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pubmed:affiliation |
Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangothri 574 199, Mangalore, Karnataka, India.
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pubmed:publicationType |
Journal Article
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