| pubmed-article:1718961 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1718961 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:1718961 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1718961 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:1718961 | lifeskim:mentions | umls-concept:C0017710 | lld:lifeskim |
| pubmed-article:1718961 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:1718961 | lifeskim:mentions | umls-concept:C0108685 | lld:lifeskim |
| pubmed-article:1718961 | lifeskim:mentions | umls-concept:C0032120 | lld:lifeskim |
| pubmed-article:1718961 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:1718961 | lifeskim:mentions | umls-concept:C1158770 | lld:lifeskim |
| pubmed-article:1718961 | lifeskim:mentions | umls-concept:C0600508 | lld:lifeskim |
| pubmed-article:1718961 | lifeskim:mentions | umls-concept:C0205390 | lld:lifeskim |
| pubmed-article:1718961 | pubmed:issue | 30 | lld:pubmed |
| pubmed-article:1718961 | pubmed:dateCreated | 1991-12-2 | lld:pubmed |
| pubmed-article:1718961 | pubmed:abstractText | Independent of de novo protein synthesis, interleukin-1, interleukin-6, and dexamethasone caused immediate stimulation of transcriptional activity of most major acute phase plasma protein genes in the rat hepatoma H-35 cells. However, activation of alpha 2-macroglobulin and alpha 1-acid glycoprotein genes were delayed by 2-4 h and required ongoing protein synthesis. The hormones also increased transiently the transcription of the junB gene and the amounts of JunB, C/EBP, and C/EBP-like mRNA. To identify whether JunB and C/EBP have the ability to control both the early and late acute phase reactants, expression vectors for mouse C/EBP and JunB together with reporter gene constructs containing recognized hormone-specific regulatory elements were introduced into hepatoma cells. C/EBP displayed prominent transactivation activity with the interleukin-1 and glucocorticoid regulatory elements of alpha 1-acid glycoprotein, the interleukin-1 regulatory element of haptoglobin gene, and the interleukin-6 regulatory element of beta-fibrinogen. The interleukin-6 regulatory elements of the first two genes and the glucocorticoid response element of the third gene were not affected by C/EBP. These data suggest that normal hormone activation of these three acute phase reactant genes might involve, in part, C/EBP-related factors which have a broad range of specificity. H-35 cells stably transformed with a mouse C/EBP expression vector showed an elevated basal level as well as cytokine inducible expression of some but not all acute phase reactants. Cotransfected JunB resulted in reduced activity of cytokine-responsive constructs and in lower transactivation by C/EBP. JunB appears to function as a modulator of plasma protein expression during the course of acute phase response. | lld:pubmed |
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| pubmed-article:1718961 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1718961 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1718961 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1718961 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1718961 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:1718961 | pubmed:author | pubmed-author:BaumannHH | lld:pubmed |
| pubmed-article:1718961 | pubmed:author | pubmed-author:JonesV EVE | lld:pubmed |
| pubmed-article:1718961 | pubmed:author | pubmed-author:WooK BKB | lld:pubmed |
| pubmed-article:1718961 | pubmed:author | pubmed-author:PruittS CSC | lld:pubmed |
| pubmed-article:1718961 | pubmed:author | pubmed-author:JahreisG PGP | lld:pubmed |
| pubmed-article:1718961 | pubmed:author | pubmed-author:MorellaK KKK | lld:pubmed |
| pubmed-article:1718961 | pubmed:author | pubmed-author:ProwseK RKR | lld:pubmed |
| pubmed-article:1718961 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1718961 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:1718961 | pubmed:volume | 266 | lld:pubmed |
| pubmed-article:1718961 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1718961 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1718961 | pubmed:pagination | 20390-9 | lld:pubmed |
| pubmed-article:1718961 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1718961 | pubmed:meshHeading | pubmed-meshheading:1718961-... | lld:pubmed |
| pubmed-article:1718961 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1718961 | pubmed:articleTitle | Transcriptional regulation through cytokine and glucocorticoid response elements of rat acute phase plasma protein genes by C/EBP and JunB. | lld:pubmed |
| pubmed-article:1718961 | pubmed:affiliation | Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263. | lld:pubmed |
| pubmed-article:1718961 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1718961 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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