17188838

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0086418, umls-concept:C0205147, umls-concept:C0936012
pubmed:issue	3
pubmed:dateCreated	2007-2-12
pubmed:abstractText	Alterations in DNA methylation have been implicated in mammalian development. Hence, the identification of tissue-specific differentially methylated regions (TDMs) is indispensable for understanding its role. Using restriction landmark genomic scanning of six mouse tissues, 150 putative TDMs were identified and 14 were further analyzed. The DNA sequences of the 14 mouse TDMs are analyzed in this study. Six of the human homologous regions show TDMs to both mouse and human and genes in five of these regions have conserved tissue-specific expression: preferential expression in testis. A TDM, DDX4, is further analyzed in nine testis tissues. An increase in methylation of the promoter region is significantly associated with a marked reduction of the gene expression and defects in spermatogenesis, suggesting that hypomethylation of the DDX4 promoter region regulates DDX4 gene expression in spermatogenic cells. Our results indicate that some genomic regions with tissue-specific methylation and expression are conserved between mouse and human and suggest that DNA methylation may have an important role in regulating differentiation and tissue-/cell-specific gene expression of some genes.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/CA102423, http://linkedlifedata.com/resource/pubmed/grant/CA16056, http://linkedlifedata.com/resource/pubmed/grant/R01 CA102423-01A1, http://linkedlifedata.com/resource/pubmed/grant/R01 ES012249-03
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8800135
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/DDX4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/DEAD-box RNA Helicases, http://linkedlifedata.com/resource/pubmed/chemical/Ddx4 protein, mouse
pubmed:status	MEDLINE
pubmed:month	Mar
pubmed:issn	0888-7543
pubmed:author	pubmed-author:GhoshSrimoyeeS, pubmed-author:HeldWilliam AWA, pubmed-author:HidaNaokoN, pubmed-author:IgarashiJunJ, pubmed-author:KitamuraEikoE, pubmed-author:MorohashiAikoA, pubmed-author:NagaseHirokiH, pubmed-author:NemotoNorimichiN, pubmed-author:OinumaToshinoriT, pubmed-author:SongFeiF, pubmed-author:Yoshida-NoroChikakoC
pubmed:issnType	Print
pubmed:volume	89
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	326-37
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:17188838-Aged, pubmed-meshheading:17188838-Aged, 80 and over, pubmed-meshheading:17188838-Animals, pubmed-meshheading:17188838-Base Sequence, pubmed-meshheading:17188838-CpG Islands, pubmed-meshheading:17188838-DEAD-box RNA Helicases, pubmed-meshheading:17188838-DNA Methylation, pubmed-meshheading:17188838-Gene Expression Regulation, pubmed-meshheading:17188838-Genome, Human, pubmed-meshheading:17188838-Humans, pubmed-meshheading:17188838-Male, pubmed-meshheading:17188838-Mice, pubmed-meshheading:17188838-Mice, Inbred C57BL, pubmed-meshheading:17188838-Middle Aged, pubmed-meshheading:17188838-Organ Specificity, pubmed-meshheading:17188838-Spermatogenesis, pubmed-meshheading:17188838-Testis
pubmed:year	2007
pubmed:articleTitle	Analysis of tissue-specific differentially methylated regions (TDMs) in humans.
pubmed:affiliation	Life Science, Advanced Research Institute for the Sciences and Humanities, Nihon University School of Medicine, Tokyo 173-8610, Japan.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural