Linked Life Data

17188572

Source:http://linkedlifedata.com/resource/pubmed/id/17188572

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-2-5
pubmed:abstractText
Negative immune regulation can result in the poor control of virus replication in chronic infections but is probably important to prevent tissue damage from chronic immune activation. Three recent studies have shown that programmed cell death (PD)-1 expression on T cells correlates with viral load in HIV infection, and that interrupting PD-1 signaling using an antagonistic antibody rejuvenates T-cell effector functions in vitro. These findings have important implications for potential therapies for chronic infection and, perhaps, for improved tumor immunity. Here, we discuss impending issues in the translation to clinical studies in light of recent adverse events with costimulatory antibody therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1471-4906
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
48-50
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
The road to recovery: translating PD-1 biology into clinical benefit.
pubmed:affiliation
Abramson Family Research Cancer Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
pubmed:publicationType
Journal Article