| pubmed-article:1718855 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1718855 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1718855 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1718855 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:1718855 | lifeskim:mentions | umls-concept:C0005767 | lld:lifeskim |
| pubmed-article:1718855 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:1718855 | lifeskim:mentions | umls-concept:C0175630 | lld:lifeskim |
| pubmed-article:1718855 | lifeskim:mentions | umls-concept:C0018517 | lld:lifeskim |
| pubmed-article:1718855 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:1718855 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1718855 | pubmed:dateCreated | 1991-12-6 | lld:pubmed |
| pubmed-article:1718855 | pubmed:abstractText | Human interleukin-6 (hIL-6) injected into mice increases antigen-specific antibody production. In the present study, we examined the possibility that anti-hIL-6 murine monoclonal antibody (MH-166) could neutralize this hIL-6 activity in vivo. Although MH166 completely neutralized hIL-6 activity in vitro, treatment in vivo with hIL-6 and MH166 combined unexpectedly increased both anti-dinitrophenyl (DNP) and anti-sheep red blood cell (SRBC) antibody production more than treatment with IL-6 alone did. To explain this phenomenon, the serum hIL-6 level was monitored following the MH166 administration. The hIL-6 level was significantly higher in the mice treated with both hIL-6 and MH166 than in the mice treated with hIL-6 alone during the 24 hr following hIL-6 administration. These results indicate that MH166 prolongs half-life of a xenogeneic hIL-6. | lld:pubmed |
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| pubmed-article:1718855 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1718855 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1718855 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1718855 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:1718855 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1718855 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1718855 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:1718855 | pubmed:author | pubmed-author:FukuiHH | lld:pubmed |
| pubmed-article:1718855 | pubmed:author | pubmed-author:OhsugiYY | lld:pubmed |
| pubmed-article:1718855 | pubmed:author | pubmed-author:YasukawaKK | lld:pubmed |
| pubmed-article:1718855 | pubmed:author | pubmed-author:MiharaMM | lld:pubmed |
| pubmed-article:1718855 | pubmed:author | pubmed-author:KoishiharaYY | lld:pubmed |
| pubmed-article:1718855 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1718855 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:1718855 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1718855 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1718855 | pubmed:pagination | 55-9 | lld:pubmed |
| pubmed-article:1718855 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1718855 | pubmed:meshHeading | pubmed-meshheading:1718855-... | lld:pubmed |
| pubmed-article:1718855 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1718855 | pubmed:articleTitle | Murine anti-human IL-6 monoclonal antibody prolongs the half-life in circulating blood and thus prolongs the bioactivity of human IL-6 in mice. | lld:pubmed |
| pubmed-article:1718855 | pubmed:affiliation | Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co. Ltd, Shizuoka, Japan. | lld:pubmed |
| pubmed-article:1718855 | pubmed:publicationType | Journal Article | lld:pubmed |
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