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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-12-6
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pubmed:abstractText |
Human interleukin-6 (hIL-6) injected into mice increases antigen-specific antibody production. In the present study, we examined the possibility that anti-hIL-6 murine monoclonal antibody (MH-166) could neutralize this hIL-6 activity in vivo. Although MH166 completely neutralized hIL-6 activity in vitro, treatment in vivo with hIL-6 and MH166 combined unexpectedly increased both anti-dinitrophenyl (DNP) and anti-sheep red blood cell (SRBC) antibody production more than treatment with IL-6 alone did. To explain this phenomenon, the serum hIL-6 level was monitored following the MH166 administration. The hIL-6 level was significantly higher in the mice treated with both hIL-6 and MH166 than in the mice treated with hIL-6 alone during the 24 hr following hIL-6 administration. These results indicate that MH166 prolongs half-life of a xenogeneic hIL-6.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1718855-2086490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1718855-2265491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1718855-2410927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1718855-2454191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1718855-2459240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1718855-2464026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1718855-2487674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1718855-2536900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1718855-2788282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1718855-2948184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1718855-3257241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1718855-3258006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1718855-3258060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1718855-3260187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1718855-3261754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1718855-3264880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1718855-3494671
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
55-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1718855-Animals,
pubmed-meshheading:1718855-Antibodies, Monoclonal,
pubmed-meshheading:1718855-Antibody Formation,
pubmed-meshheading:1718855-Dinitrophenols,
pubmed-meshheading:1718855-Epitopes,
pubmed-meshheading:1718855-Female,
pubmed-meshheading:1718855-Half-Life,
pubmed-meshheading:1718855-Humans,
pubmed-meshheading:1718855-Immunoglobulin G,
pubmed-meshheading:1718855-Immunoglobulin M,
pubmed-meshheading:1718855-Interleukin-6,
pubmed-meshheading:1718855-Mice,
pubmed-meshheading:1718855-Mice, Inbred Strains
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pubmed:year |
1991
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pubmed:articleTitle |
Murine anti-human IL-6 monoclonal antibody prolongs the half-life in circulating blood and thus prolongs the bioactivity of human IL-6 in mice.
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pubmed:affiliation |
Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co. Ltd, Shizuoka, Japan.
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pubmed:publicationType |
Journal Article
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