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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2007-1-15
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pubmed:abstractText |
HIV-1 entry into cells is a multifaceted process involving target cell CD4 and the chemokine receptors, CXCR4 or CCR5. The lipid composition of the host cell plays a significant role in the HIV fusion process as it orchestrates the appropriate disposition of CD4 and co-receptors required for HIV-1 envelope glycoprotein (Env)-mediated fusion. The cell membrane is primarily composed of sphingolipids and cholesterol. The effects of lipid modulation on CD4 disposition in the membrane and their role in HIV-1 entry have extensively been studied. To focus on the role of lipid composition on chemokine receptor function, we have by-passed the CD4 requirement for HIV-1 Env-mediated fusion by using a CD4-independent strain of HIV-1 Env.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17187670-10339592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17187670-10559349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17187670-10864648,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17187670-11485618,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17187670-11937572,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17187670-9632381
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, env,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/Sphingolipids
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pubmed:status |
MEDLINE
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pubmed:issn |
1743-422X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
104
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17187670-Animals,
pubmed-meshheading:17187670-Antigens, CD4,
pubmed-meshheading:17187670-Cell Fusion,
pubmed-meshheading:17187670-Cholesterol,
pubmed-meshheading:17187670-Gene Products, env,
pubmed-meshheading:17187670-HIV-1,
pubmed-meshheading:17187670-Humans,
pubmed-meshheading:17187670-Membrane Fusion,
pubmed-meshheading:17187670-Mice,
pubmed-meshheading:17187670-NIH 3T3 Cells,
pubmed-meshheading:17187670-Receptors, CCR5,
pubmed-meshheading:17187670-Receptors, CXCR4,
pubmed-meshheading:17187670-Receptors, Chemokine,
pubmed-meshheading:17187670-Sphingolipids
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pubmed:year |
2006
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pubmed:articleTitle |
The role of cholesterol and sphingolipids in chemokine receptor function and HIV-1 envelope glycoprotein-mediated fusion.
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pubmed:affiliation |
Center for Cancer Research Nanobiology Program, Center for Cancer Research, National Cancer Insitute, National Institutes of Health, Frederick, Maryland, USA. sablan@ncifcrf.gov
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pubmed:publicationType |
Journal Article
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