Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1991-12-13
|
| pubmed:abstractText |
There is structural and functional evidence that both class I- and II-restricted T cells recognize short processed peptides bound to MHC molecules. Although the structural conformation of bound peptides remains unknown, no evidence of distinct structural motifs of class I- or class II-restricted peptides has been described. Conversely, two algorithms proposed to predict T cell epitopes, and based on primary amino acid sequence or tertiary structure, are both compatible with many observed class I- and class II-restricted peptides. We previously identified eight class I-restricted peptides which were also recognized by class II-restricted T cells. Based on functional and direct binding studies, additional examples of peptides with both class I and II restrictions have been identified. In this study, we have directly compared the fine specificity of T cell recognition of a single epitope in a single mouse strain in the context of both class I- and class II-restricted responses. Based on a panel of analogue peptides with amino acid substitutions and peptides of various lengths, we observed several striking similarities in the recognition patterns of both class I- and class II-restricted T cells. In addition, some characteristics of recognition were different in the two systems indicating that the recognition processes were similar but not identical.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleocapsid Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Core Proteins
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0014-2980
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2781-9
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1718759-Amino Acid Sequence,
pubmed-meshheading:1718759-Animals,
pubmed-meshheading:1718759-Antigens, Viral,
pubmed-meshheading:1718759-Epitopes,
pubmed-meshheading:1718759-H-2 Antigens,
pubmed-meshheading:1718759-Histocompatibility Antigens Class II,
pubmed-meshheading:1718759-Hybridomas,
pubmed-meshheading:1718759-Influenza A virus,
pubmed-meshheading:1718759-Lymphocyte Activation,
pubmed-meshheading:1718759-Mice,
pubmed-meshheading:1718759-Mice, Inbred Strains,
pubmed-meshheading:1718759-Molecular Sequence Data,
pubmed-meshheading:1718759-Nucleocapsid Proteins,
pubmed-meshheading:1718759-Nucleoproteins,
pubmed-meshheading:1718759-Peptides,
pubmed-meshheading:1718759-Structure-Activity Relationship,
pubmed-meshheading:1718759-T-Lymphocytes,
pubmed-meshheading:1718759-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:1718759-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:1718759-Viral Core Proteins
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Comparison of class I- and II-restricted T cell recognition of the identical peptide.
|
| pubmed:affiliation |
Laboratory of Immunogenetics and Transplantation, Brigham and Women's Hospital, Boston, MA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|