Source:http://linkedlifedata.com/resource/pubmed/id/17187009
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2007-1-1
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pubmed:abstractText |
Measurable traits of human personality may mark the predisposition to psychopathology. Increased novelty seeking plays an important role in the pathogenesis of substance abuse. Novelty seeking, one of the fundamental traits of the human temperament, is related to dopamine. Catechol-O-methyltransferase (COMT) is essential for dopamine inactivation. The aim of our study was to assess whether the COMT gene Val158Met functional polymorphism in patients dependent on methamphetamine is related to their novelty seeking score.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0172-780X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
799-802
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pubmed:meshHeading |
pubmed-meshheading:17187009-Adult,
pubmed-meshheading:17187009-Catechol O-Methyltransferase,
pubmed-meshheading:17187009-Czechoslovakia,
pubmed-meshheading:17187009-Dopamine,
pubmed-meshheading:17187009-Exploratory Behavior,
pubmed-meshheading:17187009-Female,
pubmed-meshheading:17187009-Humans,
pubmed-meshheading:17187009-Male,
pubmed-meshheading:17187009-Methamphetamine,
pubmed-meshheading:17187009-Polymorphism, Single Nucleotide,
pubmed-meshheading:17187009-Substance-Related Disorders
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pubmed:year |
2006
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pubmed:articleTitle |
The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: preliminary results.
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pubmed:affiliation |
Department of Psychiatry, Charles University in Prague, Faculty of Medicine in Hradec Králové and University Hospital Hradec Králové, Czech Republic. hosak@lfhk.cuni.cz
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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