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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2006-12-21
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pubmed:abstractText |
Methotrexate (MTX) is most widely used for the treatment of rheumatoid arthritis (RA). However, it has certain drawbacks with regard to individual differences in its therapeutic effects as well as the differences in the patients' response to MTX therapy. We investigated whether multi-drug resistance-1 (ABCB1) C3435T, reduced folate carrier-1 (RFC1) G80A, 5-aminoimidazole-4-carboxamide ribonucleotide transformylase (ATIC) C347G and a 6bp-deletion polymorphism in the 3'-untranslated region of the thymidylase synthase (TYMS) gene are predictive of MTX sensitivity and its adverse effects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ABCB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Antirheumatic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethyl and Formyl...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Methotrexate,
http://linkedlifedata.com/resource/pubmed/chemical/Multienzyme Complexes,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleotide Deaminases,
http://linkedlifedata.com/resource/pubmed/chemical/Organic Anion Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/SLC19A2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Thymidylate Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/inosine monophosphate synthase
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pubmed:status |
MEDLINE
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pubmed:issn |
0392-856X
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pubmed:author |
pubmed-author:AsanoTT,
pubmed-author:FujiokaMM,
pubmed-author:HirataTT,
pubmed-author:HirotaYY,
pubmed-author:HojoTT,
pubmed-author:KawahitoYY,
pubmed-author:KubaJJ,
pubmed-author:NishinoHH,
pubmed-author:SatomiYY,
pubmed-author:TakahashiK AKA,
pubmed-author:TakatoriRR,
pubmed-author:TanakaTT,
pubmed-author:TokunagaDD
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
546-54
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:17181924-Antirheumatic Agents,
pubmed-meshheading:17181924-Arthritis, Rheumatoid,
pubmed-meshheading:17181924-Drug Resistance, Multiple,
pubmed-meshheading:17181924-Female,
pubmed-meshheading:17181924-Genotype,
pubmed-meshheading:17181924-Health Status,
pubmed-meshheading:17181924-Humans,
pubmed-meshheading:17181924-Hydroxymethyl and Formyl Transferases,
pubmed-meshheading:17181924-Joints,
pubmed-meshheading:17181924-Male,
pubmed-meshheading:17181924-Membrane Transport Proteins,
pubmed-meshheading:17181924-Methotrexate,
pubmed-meshheading:17181924-Middle Aged,
pubmed-meshheading:17181924-Multienzyme Complexes,
pubmed-meshheading:17181924-Nucleotide Deaminases,
pubmed-meshheading:17181924-Organic Anion Transporters,
pubmed-meshheading:17181924-P-Glycoprotein,
pubmed-meshheading:17181924-Polymorphism, Genetic,
pubmed-meshheading:17181924-Retrospective Studies,
pubmed-meshheading:17181924-Severity of Illness Index,
pubmed-meshheading:17181924-Thymidylate Synthase,
pubmed-meshheading:17181924-Treatment Outcome
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pubmed:articleTitle |
ABCB1 C3435T polymorphism influences methotrexate sensitivity in rheumatoid arthritis patients.
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pubmed:affiliation |
Dept. of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. r-taka@koto.kpu-m.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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