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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2006-12-21
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pubmed:abstractText |
The year 2006 will mark a turning point in the daily management of patients with metastatic renal cell carcinoma. The impact of immunotherapy with interferon-alpha or interleukin-2 has been shown to be restricted to a minority of patients. The growing understanding of molecular mechanisms involved in the pathogenesis of the disease, especially clear-cell carcinoma, has led to the development of multiple targeted therapies with significant clinical benefits. Two compounds that predominantly inhibit the tyrosine kinase activity of the vascular endothelial growth factor receptor have been shown to improve the progression-free survival of patients in first- (sunitinib versus interferon-alpha) or second-line (sorafenib versus placebo) treatment. Temsirolimus, an agent that inhibits the serine-threonine kinase activity of the mammalian target of rapamycin, offers better overall survival than interferon in patients with poor-risk characteristics. Further studies are needed to determine the optimal combinations of these agents in metastatic disease and to assess their impact in the adjuvant setting.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, Humanized,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzenesulfonates,
http://linkedlifedata.com/resource/pubmed/chemical/Immunologic Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/MTOR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Vascular Endothelial...,
http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus,
http://linkedlifedata.com/resource/pubmed/chemical/TOR Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/bevacizumab,
http://linkedlifedata.com/resource/pubmed/chemical/sorafenib,
http://linkedlifedata.com/resource/pubmed/chemical/sunitinib,
http://linkedlifedata.com/resource/pubmed/chemical/temsirolimus
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1744-8328
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1761-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17181490-Angiogenesis Inhibitors,
pubmed-meshheading:17181490-Antibodies, Monoclonal,
pubmed-meshheading:17181490-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:17181490-Antineoplastic Agents,
pubmed-meshheading:17181490-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:17181490-Benzenesulfonates,
pubmed-meshheading:17181490-Carcinoma, Renal Cell,
pubmed-meshheading:17181490-Chemotherapy, Adjuvant,
pubmed-meshheading:17181490-Drug Delivery Systems,
pubmed-meshheading:17181490-Drug Therapy, Combination,
pubmed-meshheading:17181490-Forecasting,
pubmed-meshheading:17181490-Humans,
pubmed-meshheading:17181490-Immunologic Factors,
pubmed-meshheading:17181490-Immunotherapy,
pubmed-meshheading:17181490-Indoles,
pubmed-meshheading:17181490-Interferon-alpha,
pubmed-meshheading:17181490-Interleukin-2,
pubmed-meshheading:17181490-Kidney Neoplasms,
pubmed-meshheading:17181490-Neoplasm Proteins,
pubmed-meshheading:17181490-Protein Kinase Inhibitors,
pubmed-meshheading:17181490-Protein Kinases,
pubmed-meshheading:17181490-Pyridines,
pubmed-meshheading:17181490-Pyrroles,
pubmed-meshheading:17181490-Receptors, Vascular Endothelial Growth Factor,
pubmed-meshheading:17181490-Sirolimus,
pubmed-meshheading:17181490-TOR Serine-Threonine Kinases
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pubmed:year |
2006
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pubmed:articleTitle |
Targeted therapies in metastatic renal cell carcinoma: the light at the end of the tunnel.
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pubmed:affiliation |
Department of Medical Oncology, CRLC Val d'Aurelle, Parc Euromédecine, 34298--Montpellier Cedex 5, France.
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pubmed:publicationType |
Journal Article,
Review
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