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rdf:type |
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lifeskim:mentions |
umls-concept:C0031689,
umls-concept:C0033681,
umls-concept:C0034790,
umls-concept:C0041485,
umls-concept:C0332281,
umls-concept:C0337112,
umls-concept:C1421567,
umls-concept:C1524075,
umls-concept:C1527940,
umls-concept:C1705831,
umls-concept:C1719914,
umls-concept:C1948023,
umls-concept:C2828406
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pubmed:issue |
20
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pubmed:dateCreated |
1991-11-15
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pubmed:abstractText |
Stimulation of the T-cell antigen receptor (TCR) leads to tyrosine phosphorylation of a number of cellular proteins, including phospholipase C (PLC) gamma 1 and the TCR zeta chain. We describe here a 70-kDa tyrosine phosphoprotein (ZAP-70) that associates with zeta within 15 sec following TCR stimulation. The phosphorylation of ZAP-70 and its association with zeta is independent of the other TCR chains since stimulation of a functional CD8/zeta chimeric receptor in a TCR-negative T cell leads to coprecipitation of ZAP-70 with the chimeric protein. In a Jurkat cell expressing the TCR and the CD8/zeta chimeric protein, tyrosine phosphorylation and association of ZAP-70 occurs exclusively with the stimulated receptor complex. In addition, a tyrosine kinase that does not appear to be fyn associates with the cytoplasmic domain of zeta and phosphorylates zeta and ZAP-70 in vitro.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-1671341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-1688582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-1689750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-1694265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-1695377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-1700866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-1705867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-1706070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-1708916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-1712101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-1846320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-1964053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-2015626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-2117633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-2143190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-2185544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-2190221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-2463167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-2470098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-2476487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-2528695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-2542295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-2545680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-2768241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-2786526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-2961214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-3262426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-3278377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-3289580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-6246487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1717999-6316339
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/antigen T cell receptor, zeta chain
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9166-70
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1717999-Amino Acids,
pubmed-meshheading:1717999-Antigens, CD8,
pubmed-meshheading:1717999-Cell Line,
pubmed-meshheading:1717999-Humans,
pubmed-meshheading:1717999-Kinetics,
pubmed-meshheading:1717999-Macromolecular Substances,
pubmed-meshheading:1717999-Membrane Glycoproteins,
pubmed-meshheading:1717999-Membrane Proteins,
pubmed-meshheading:1717999-Molecular Weight,
pubmed-meshheading:1717999-Phosphoproteins,
pubmed-meshheading:1717999-Phosphorylation,
pubmed-meshheading:1717999-Phosphotyrosine,
pubmed-meshheading:1717999-Protein-Tyrosine Kinases,
pubmed-meshheading:1717999-Receptors, Antigen, T-Cell,
pubmed-meshheading:1717999-Transfection,
pubmed-meshheading:1717999-Tyrosine
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pubmed:year |
1991
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pubmed:articleTitle |
The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.
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pubmed:affiliation |
Division of Rheumatology, Howard Hughes Medical Institute, University of California, San Francisco 94143.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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