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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-12-20
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pubmed:abstractText |
Roflumilast is an oral, once-daily phosphodiesterase 4 inhibitor under investigation for the treatment of chronic obstructive pulmonary disease and asthma. In clinical practice, the drug is likely to be co-administered with inhaled bronchodilating beta2-adrenoceptor agonists. Therefore, this study investigated the pharmacokinetic characteristics of roflumilast and its pharmacodynamically active metabolite roflumilast N-oxide when co-administered with orally inhaled salbutamol in healthy subjects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0946-1965
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pubmed:author |
pubmed-author:BethkeT DTD,
pubmed-author:DavidMM,
pubmed-author:GiessmannTT,
pubmed-author:HaunsBB,
pubmed-author:HauschkeDD,
pubmed-author:HermannRR,
pubmed-author:LaibKK,
pubmed-author:SiegmundWW,
pubmed-author:WeinbrennerAA,
pubmed-author:WestphalKK,
pubmed-author:ZechKK
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
572-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17176624-Adrenergic beta-Agonists,
pubmed-meshheading:17176624-Adult,
pubmed-meshheading:17176624-Albuterol,
pubmed-meshheading:17176624-Aminopyridines,
pubmed-meshheading:17176624-Benzamides,
pubmed-meshheading:17176624-Bronchodilator Agents,
pubmed-meshheading:17176624-Cyclopropanes,
pubmed-meshheading:17176624-Drug Interactions,
pubmed-meshheading:17176624-Humans,
pubmed-meshheading:17176624-Male,
pubmed-meshheading:17176624-Phosphodiesterase Inhibitors
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pubmed:year |
2006
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pubmed:articleTitle |
Roflumilast, a once-daily oral phosphodiesterase 4 inhibitor, lacks relevant pharmacokinetic interactions with inhaled salbutamol when co-administered in healthy subjects.
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pubmed:affiliation |
ALTANA Pharma AG, Konstanz, Germany.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial
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