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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-12-19
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pubmed:abstractText |
Glyceollins are a novel class of soybean phytoalexins with potential cancer-protective antiestrogenic effects. The purpose of this study was to evaluate the estrogen-antagonist effects of glyceollin-enriched soy protein on biomarkers for breast cancer risk. Thirty female postmenopausal cynomolgus macaques were randomized to one of three dietary treatments for 3 wk: 1) estradiol (E2, 1 mg/day) + casein/lactalbumin (control); 2) E2 + soy protein isolate (SPI) containing 194 mg/day isoflavonoids; and 3) E2 + glyceollin-enriched soy protein (GLY) containing 189 mg/day isoflavonoids + 134 mg/day glyceollins. Doses are expressed in calorically scaled human equivalents. Mean serum glyceollin concentrations at 4 h postfeeding were 134.2 +/- 34.6 nmol/L in the GLY group and negligible in the SPI group (P = 0.0007). Breast proliferation was significantly increased in the control group (+237%, P = 0.01) but not in the SPI group (+198%, P = 0.08) or GLY group (+36%, P = 0.18). Gene expression of trefoil factor 1 and progesterone receptor, two markers of estrogen receptor activity in breast epithelium, were also significantly higher in the control (P < 0.05 for both) but not in the GLY group. These preliminary findings suggest that soybean glyceollins are natural compounds with potential estrogen-modulating properties in the breast.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anticarcinogenic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzopyrans,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Isoflavones,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Pterocarpans,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/Soybean Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/glyceollin,
http://linkedlifedata.com/resource/pubmed/chemical/trefoil factor
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pubmed:status |
MEDLINE
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pubmed:issn |
0163-5581
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
74-81
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17176220-Animals,
pubmed-meshheading:17176220-Anticarcinogenic Agents,
pubmed-meshheading:17176220-Benzopyrans,
pubmed-meshheading:17176220-Biological Markers,
pubmed-meshheading:17176220-Breast Neoplasms,
pubmed-meshheading:17176220-Estradiol,
pubmed-meshheading:17176220-Female,
pubmed-meshheading:17176220-Gene Expression,
pubmed-meshheading:17176220-Immunohistochemistry,
pubmed-meshheading:17176220-Isoflavones,
pubmed-meshheading:17176220-Macaca fascicularis,
pubmed-meshheading:17176220-Mammary Glands, Animal,
pubmed-meshheading:17176220-Ovariectomy,
pubmed-meshheading:17176220-Peptides,
pubmed-meshheading:17176220-Postmenopause,
pubmed-meshheading:17176220-Pterocarpans,
pubmed-meshheading:17176220-Receptors, Progesterone,
pubmed-meshheading:17176220-Soybean Proteins,
pubmed-meshheading:17176220-Soybeans,
pubmed-meshheading:17176220-Tumor Markers, Biological
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pubmed:year |
2006
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pubmed:articleTitle |
Effects of soybean glyceollins and estradiol in postmenopausal female monkeys.
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pubmed:affiliation |
Department of Pathology/Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. chwood@wfubmc.edu
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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