Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-1-23
pubmed:abstractText
The activating cytotoxicity receptor NKG2D binds to stress-regulated molecules encoded by the major histocompatibility complex class I chain-related (MIC) and UL-16-binding protein (ULBP)/retinoic acid early transcript (RAET) gene family. To assess whether acute allograft rejection leads to an induction of these inducible ligands and their receptor NKG2D, we examined the mRNA profiles in kidney transplant biopsies. Expression levels were correlated with the incidence of acute rejection (aRx) episodes and chronic allograft nephropathy (CAN) proven by histology. Whereas MICA, ULBP1/3 and RAET1-E did not display heightened gene expression, elevated levels of NKG2D mRNA could be associated with aRx (p < 0.001). Immunohistology of kidney biopsies diagnosed with aRx revealed NKG2D+ cells in tubulointerstitial areas positive for CD8+ cells. Most importantly, elevated levels of NKG2D mRNA were associated with restricted long-term graft function assessed by the glomerular filtration rate at 6, 12 and 18 months posttransplantation. Induced NKG2D mRNA expression was still observable in biopsies diagnosed with CAN (p < 0.001), demonstrating a higher sensitivity and specificity compared to CD3, granzyme B and granulysin mRNA measurement. Significant elevated levels of NKG2D mRNA could be further detected in urine sediment prior to aRx, suggesting this receptor as a new candidate marker for the diagnosis of acute and chronic allograft rejection.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1600-6135
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
423-33
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:17173658-Acute Disease, pubmed-meshheading:17173658-Adolescent, pubmed-meshheading:17173658-Adult, pubmed-meshheading:17173658-Aged, pubmed-meshheading:17173658-Aged, 80 and over, pubmed-meshheading:17173658-Biopsy, pubmed-meshheading:17173658-Chronic Disease, pubmed-meshheading:17173658-Female, pubmed-meshheading:17173658-Gene Expression Regulation, pubmed-meshheading:17173658-Graft Rejection, pubmed-meshheading:17173658-Histocompatibility Antigens Class I, pubmed-meshheading:17173658-Humans, pubmed-meshheading:17173658-Kidney Diseases, pubmed-meshheading:17173658-Kidney Transplantation, pubmed-meshheading:17173658-Male, pubmed-meshheading:17173658-Middle Aged, pubmed-meshheading:17173658-NK Cell Lectin-Like Receptor Subfamily K, pubmed-meshheading:17173658-RNA, Messenger, pubmed-meshheading:17173658-Receptors, Immunologic, pubmed-meshheading:17173658-Receptors, Natural Killer Cell
pubmed:year
2007
pubmed:articleTitle
Heightened expression of the cytotoxicity receptor NKG2D correlates with acute and chronic nephropathy after kidney transplantation.
pubmed:affiliation
Institute of Medical Immunology, Universitätsmedizin Charité, Campus Mitte, Berlin, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't