Source:http://linkedlifedata.com/resource/pubmed/id/17171760
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2006-12-27
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| pubmed:abstractText |
Germinal centers support the differentiation of memory B cells and long-lived antibody-secreting cells during infection or upon vaccination. Here, we constructed mice with T cells that selectively lack the chemokine receptor CXCR5 to determine if expression of this receptor by T cells is mandatory for germinal center formation and function. In these animals, germinal centers that are properly localized in B cell follicles and contain T cells do form after immunization with a thymus-dependent antigen. However, fewer and smaller germinal centers form, resulting in a significant reduction in the frequency of germinal center B cells. The defect in germinal center formation is paralleled by decreased frequencies of isotype-switched antibody-secreting cells in the spleen and bone marrow and reduced serum concentrations of total and high-affinity hapten-specific IgG1. The results demonstrate that although CXCR5-dependent T cell positioning is important for maximal induction and expansion of germinal centers, stimulation of isotype class switching, and development of antibody-secreting cells that seed the spleen and bone marrow, it is not absolutely required for the formation and function of follicular germinal centers.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blr1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Isotypes,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0014-2980
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
37
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
100-9
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:17171760-Animals,
pubmed-meshheading:17171760-B-Lymphocyte Subsets,
pubmed-meshheading:17171760-Bone Marrow Cells,
pubmed-meshheading:17171760-Cell Differentiation,
pubmed-meshheading:17171760-Chemotaxis, Leukocyte,
pubmed-meshheading:17171760-Crosses, Genetic,
pubmed-meshheading:17171760-Germinal Center,
pubmed-meshheading:17171760-Immunoglobulin Class Switching,
pubmed-meshheading:17171760-Immunoglobulin Isotypes,
pubmed-meshheading:17171760-Mice,
pubmed-meshheading:17171760-Mice, Inbred C57BL,
pubmed-meshheading:17171760-Mice, Knockout,
pubmed-meshheading:17171760-Radiation Chimera,
pubmed-meshheading:17171760-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:17171760-Receptors, CXCR5,
pubmed-meshheading:17171760-Receptors, Chemokine,
pubmed-meshheading:17171760-Spleen,
pubmed-meshheading:17171760-T-Lymphocyte Subsets
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| pubmed:year |
2007
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| pubmed:articleTitle |
The germinal center response is impaired in the absence of T cell-expressed CXCR5.
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| pubmed:affiliation |
Department of Pathology, Laboratory of Immunology and Vascular Biology, Stanford University School of Medicine, Stanford, CA, USA. cnarnold@scripps.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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