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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-5-16
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pubmed:abstractText |
An untreated 66-year-old woman with chronic myelogenous leukaemia (CML) in the chronic phase was initially given imatinib mesylate, rapidly achieving a good cytogenetic response with treatment. However, acute promyelocytic leukaemia complicated by a disseminated intravascular coagulation occurred 9 months after beginning imatinib treatment. Promyelocytic crisis of CML was diagnosed by demonstration of both BCR/ABL and PML/RAR alpha chimeric genes in leukaemic cells by karyotypic and fluorescence in situ hybridization analysis. Clonal evolution with addition of the PML/RAR alpha translocation may have arisen in the early chronic phase of CML, with expansion of this clone during imatinib treatment. Promyelocytic crisis of CML is rare; furthermore, we know of no previous report of promyelocytic crisis occurring during treatment with imatinib.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1421-9662
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pubmed:author |
pubmed-author:HashiguchiMichitoshiM,
pubmed-author:ImamuraRieR,
pubmed-author:NagataShuichiroS,
pubmed-author:OgataHideakiH,
pubmed-author:OkamuraTakashiT,
pubmed-author:OkuEijiroE,
pubmed-author:OsakiKoichiK,
pubmed-author:OtsuboKorenoriK,
pubmed-author:SataMichioM,
pubmed-author:SekiRitsukoR,
pubmed-author:TakataYukaY,
pubmed-author:YakushijiKazuakiK,
pubmed-author:YoshimotoKohjiK
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pubmed:copyrightInfo |
2007 S. Karger AG, Basel
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pubmed:issnType |
Electronic
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pubmed:volume |
117
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
191-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:17170522-Aged,
pubmed-meshheading:17170522-Antineoplastic Agents,
pubmed-meshheading:17170522-Flow Cytometry,
pubmed-meshheading:17170522-Humans,
pubmed-meshheading:17170522-Immunophenotyping,
pubmed-meshheading:17170522-In Situ Hybridization, Fluorescence,
pubmed-meshheading:17170522-Karyotyping,
pubmed-meshheading:17170522-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:17170522-Male,
pubmed-meshheading:17170522-Piperazines,
pubmed-meshheading:17170522-Pyrimidines,
pubmed-meshheading:17170522-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2007
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pubmed:articleTitle |
Promyelocytic crisis of chronic myelogenous leukaemia during imatinib mesylate treatment.
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pubmed:affiliation |
Division of Haematology, Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan.
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pubmed:publicationType |
Journal Article,
Case Reports
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