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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-2-15
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pubmed:abstractText |
Integrins are attractive therapeutic targets. Inhibition of integrin alphaIIb beta3 effectively blocks platelet aggregation. However, limitations with intravenous alphaIIb beta3 antagonists and failure of oral alphaIIb beta3 antagonists prompted doubts on the current concept of ligand-mimetic integrin blockade.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1524-4636
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pubmed:author |
pubmed-author:AhrensIngoI,
pubmed-author:BasslerNicoleN,
pubmed-author:BodeChristophC,
pubmed-author:EisenhardtSteffen USU,
pubmed-author:HagemeyerChristoph ECE,
pubmed-author:JacksonShaun PSP,
pubmed-author:LoefflerChristophC,
pubmed-author:ManginPierreP,
pubmed-author:PeterKarlheinzK,
pubmed-author:SchwarzMeikeM,
pubmed-author:YuanYupingY
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pubmed:issnType |
Electronic
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e9-15
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pubmed:meshHeading |
pubmed-meshheading:17170374-Cell Adhesion,
pubmed-meshheading:17170374-Fluorescent Antibody Technique,
pubmed-meshheading:17170374-Humans,
pubmed-meshheading:17170374-Ligands,
pubmed-meshheading:17170374-Models, Biological,
pubmed-meshheading:17170374-Platelet Activation,
pubmed-meshheading:17170374-Platelet Aggregation Inhibitors,
pubmed-meshheading:17170374-Platelet Glycoprotein GPIIb-IIIa Complex,
pubmed-meshheading:17170374-Sensitivity and Specificity,
pubmed-meshheading:17170374-Signal Transduction
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pubmed:year |
2007
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pubmed:articleTitle |
A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIb beta3 (GPIIb/IIIa) antagonists.
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pubmed:affiliation |
Centre for Thrombosis & Myocardial Infarction, Baker Heart Research Institute, PO Box 6492 St Kilda Road Central, Melbourne, Victoria 8008, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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