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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0007090,
umls-concept:C0007586,
umls-concept:C0017262,
umls-concept:C0185117,
umls-concept:C0538674,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2825032,
umls-concept:C2911684,
umls-concept:C2911692
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pubmed:dateCreated |
2007-1-16
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pubmed:abstractText |
Chronic injury deregulates cellular homeostasis and induces a number of alterations leading to disruption of cellular processes such as cell cycle checkpoints and apoptosis, driving to carcinogenesis. The stress protein heme oxygenase-1 (HO-1) catalyzes heme degradation producing biliverdin, iron and CO. Induction of HO-1 has been suggested to be essential for a controlled cell growth. The aim of this work was to analyze the in vivo homeostatic response (HR) triggered by the withdrawal of a potent carcinogen, p-dimethylaminoazobenzene (DAB), after preneoplastic lesions were observed. We analyzed HO-1 cellular localization and the expression of HO-1, Bcl-2 and cell cycle related proteins under these conditions comparing them to hepatocellular carcinoma (HC).
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-10347107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-10424595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-10521239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-11368354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-11379353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-11737592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-11821745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-12134106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-12198654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-12490302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-12915914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-14519627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-14522248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-14525760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-14528286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-15203109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-15588927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-15592751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-15643987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-16175600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-16183036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-16530877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-2426724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-8679227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-9352304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-9407320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-9502413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17169158-9840120
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
286
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17169158-Animals,
pubmed-meshheading:17169158-Carcinogens,
pubmed-meshheading:17169158-Carcinoma, Hepatocellular,
pubmed-meshheading:17169158-Cell Cycle,
pubmed-meshheading:17169158-Cell Cycle Proteins,
pubmed-meshheading:17169158-Drug Administration Schedule,
pubmed-meshheading:17169158-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:17169158-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17169158-Heme Oxygenase-1,
pubmed-meshheading:17169158-Homeostasis,
pubmed-meshheading:17169158-Liver Neoplasms,
pubmed-meshheading:17169158-Male,
pubmed-meshheading:17169158-Mice,
pubmed-meshheading:17169158-Mice, Inbred Strains,
pubmed-meshheading:17169158-p-Dimethylaminoazobenzene
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pubmed:year |
2006
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pubmed:articleTitle |
Homeostatic response under carcinogen withdrawal, heme oxygenase 1 expression and cell cycle association.
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pubmed:affiliation |
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, CONICET Buenos Aires, Argentina. cynthiac@qb.fcen.uba.ar <cynthiac@qb.fcen.uba.ar>
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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