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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1991-10-28
|
| pubmed:abstractText |
The mean total serum amylase levels in patients was 3.2 +/- 0.5 mukat/l (+/-SE) before total body irradiation (TBI) prior to bone marrow transplantation of which 50% was due to pancreatic isoamylase and 50% salivary isoamylase. Total serum amylase increased to a maximum of 100.3 +/- 12.3 mukat/l on the first day after TBI and most of this increase was due to an increase in salivary isoamylase (90.0 +/- 12.1 mukat/l). In association with this, all patients had clinical symptoms of parotitis. An increase in pancreatic isoamylase was found in 27% of the patients; however, none of them had clinical symptoms of pancreatitis. Serum amylase levels returned to normal within 5 days after TBI but then decreased to subnormal values, remaining below the normal range for 3 weeks. Pancreatic isoamylase returned to pre-irradiation levels 1.5 months after TBI, while salivary isoamylase remained low for the rest of the observation time. TBI of 7.5 Gy at 26 cGy/min gave significantly lower salivary amylase at 2 days after TBI compared with 10 Gy at 4 cGy/min: 32 +/- 4 versus 76 +/- 13 mukat/l (P less than 0.05). At 2.5 and 6 months after TBI significantly higher total amylase levels were recorded for patients treated with 7.5 Gy of TBI compared with 10 Gy: 2.5 +/- 0.4 and 2.7 +/- 0.3 versus 2.0 +/- 0.5 and 0.8 +/- 0.3 mukat/l, respectively (P less than 0.01, P less than 0.05, respectively). Acute or chronic GVHD did not affect acinar cells in this investigation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0934-0874
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
96-8
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1716901-Adolescent,
pubmed-meshheading:1716901-Adult,
pubmed-meshheading:1716901-Amylases,
pubmed-meshheading:1716901-Bone Marrow Transplantation,
pubmed-meshheading:1716901-Child,
pubmed-meshheading:1716901-Child, Preschool,
pubmed-meshheading:1716901-Graft vs Host Disease,
pubmed-meshheading:1716901-Humans,
pubmed-meshheading:1716901-Isoamylase,
pubmed-meshheading:1716901-Leukemia,
pubmed-meshheading:1716901-Middle Aged,
pubmed-meshheading:1716901-Saliva,
pubmed-meshheading:1716901-Whole-Body Irradiation
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Isoamylase levels in bone marrow transplant patients are affected by total body irradiation and not by graft-versus-host disease.
|
| pubmed:affiliation |
Department of Transplantation Surgery, Karolinska Institute, Huddinge Hospital, Sweden.
|
| pubmed:publicationType |
Journal Article
|