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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1991-10-22
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pubmed:abstractText |
We have examined the effect of inflammatory cytokines on the platelet activation. IL-1 beta and IFN-gamma were found to enhance the adhesion of thrombin-treated platelets to monocytic leukemia cells (U937), when the adhesion was assayed by platelet-mediated cell agglutination. The agglutination was inhibited by a monoclonal anti-GMP140 antibody or EDTA, suggesting that the enhanced platelet adhesion to the leukemic cells was mediated by GMP140. In addition, these cytokines also increased the release of 5-HT from platelets in the presence of a low concentration of thrombin. These data suggest that platelet functions are regulated by the cytokines and that activated platelets participate in inflammatory process.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-291X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
179
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
756-61
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1716887-Blood Platelets,
pubmed-meshheading:1716887-Cell Adhesion Molecules,
pubmed-meshheading:1716887-Cell Line,
pubmed-meshheading:1716887-Humans,
pubmed-meshheading:1716887-Interferon-gamma,
pubmed-meshheading:1716887-Interleukin-1,
pubmed-meshheading:1716887-Monocytes,
pubmed-meshheading:1716887-P-Selectin,
pubmed-meshheading:1716887-Platelet Activation,
pubmed-meshheading:1716887-Platelet Adhesiveness,
pubmed-meshheading:1716887-Platelet Aggregation,
pubmed-meshheading:1716887-Platelet Membrane Glycoproteins,
pubmed-meshheading:1716887-Recombinant Proteins
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pubmed:year |
1991
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pubmed:articleTitle |
Enhancement by IL-1 beta and IFN-gamma of platelet activation: adhesion to leukocytes via GMP-140/PADGEM protein (CD62).
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pubmed:affiliation |
Division of Chemical Toxicology and Immunochemistry, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
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pubmed:publicationType |
Journal Article
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