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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2006-12-15
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pubmed:abstractText |
Intracellular Galpha subunits represent potential therapeutic targets for a number of diseases. Here we describe three classes of new molecules that modulate G protein signaling by direct targeting of Galpha. Using messenger RNA display, we have identified unique peptide sequences that bind Galpha i1 . Functionally, individual peptides were found that either enhance or repress basal levels of G protein-activated inwardly rectifying potassium (GIRK) channel signaling, a downstream effector of G protein activation, indicating that the peptides directly turn G proteins on or off in vivo . A third functional class acts as a signaling attenuator; basal GIRK channel activity is unaffected but responses to repeated G protein activation are reduced. These data demonstrate that G protein-directed ligands can achieve physiological effects similar to those resulting from classical receptor targeting and may serve as leads for developing new classes of therapeutics.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-10188585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-10366866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-10625628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-10969064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-11179221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-11756403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-12023121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-12040175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-12633996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-12719528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-14746508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-15189163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-15248784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-15748159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-15950876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-15980016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-16051611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-16627746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-3113327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-8401210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-8910288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-9108480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-9131251,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-9356443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17168552-9565765
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1554-8937
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
24
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
570-4
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:17168552-Amino Acid Sequence,
pubmed-meshheading:17168552-Biochemistry,
pubmed-meshheading:17168552-Cell Line,
pubmed-meshheading:17168552-DNA, Complementary,
pubmed-meshheading:17168552-Electrophysiology,
pubmed-meshheading:17168552-G Protein-Coupled Inwardly-Rectifying Potassium Channels,
pubmed-meshheading:17168552-GTP-Binding Proteins,
pubmed-meshheading:17168552-Gene Expression Regulation,
pubmed-meshheading:17168552-Humans,
pubmed-meshheading:17168552-Immunoprecipitation,
pubmed-meshheading:17168552-Ligands,
pubmed-meshheading:17168552-Molecular Sequence Data,
pubmed-meshheading:17168552-Peptides,
pubmed-meshheading:17168552-Sequence Homology, Amino Acid,
pubmed-meshheading:17168552-Signal Transduction
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pubmed:year |
2006
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pubmed:articleTitle |
Turning G proteins on and off using peptide ligands.
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pubmed:affiliation |
Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.
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pubmed:publicationType |
Letter,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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