Linked Life Data

1716814

Source:http://linkedlifedata.com/resource/pubmed/id/1716814

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-10-24
pubmed:abstractText
The non-invasive technique of laser-Doppler flowmeter (LDF) was used to measure the change of cutaneous blood flow evoked by electric stimulation of rat sciatic nerve. The sciatic nerve was cut centrally and placed on bipolar electrodes. Drug were infused in a carotid artery. Electric stimulation of the sciatic nerve containing sensory afferent fibers caused an increase in cutaneous blood flow. This increase was not modified by the ia infusion of adrenergic blocking agents (phentolamine, 0.1 mg/kg and propranolol, 0.5 mg/kg), anti-muscarinic agent (atropine 0.5 mg/kg), anti-histamines (mepyramine, 10 mg/kg and cimetidine, 10 mg/kg) and 5-HT antagonist (methysergide, 0.5 mg/kg). Pretreatment with capsaicin (50 mg/kg, sc) in the newborn rat or the ia infusion of spantide (1, 2 mumol/kg) significantly inhibited the the stimulation-induced increase of the blood flow. These results suggest that substance P released from the peripheral endings of sensory nerve may be involved in vasodilation following electric stimulation of the sciatic nerve in rat.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0253-9756
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
371-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[Effects of 7 drugs on cutaneous blood flow evoked by electric stimulation of rat sciatic nerve].
pubmed:affiliation
Department of Pharmacology, Faculty of Dentistry, Osaka University, Japan.
pubmed:publicationType
Journal Article, English Abstract