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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1991-10-21
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pubmed:abstractText |
Binding of secretory IgA (sIgA) to human milk macrophages was identified by rosette formation with sIgA-sensitized indicator cells and competitive inhibition binding studies with [125I]-sIgA. Macrophages formed rosettes with sIgA-sensitized sheep red blood cells that were inhibited by sIgA (87%) but not IgG. Both IgA1 and IgA2 inhibited sIgA-sensitized sheep red blood cell rosette formation. Rosette formation was completely inhibited by galactose, partially inhibited by asialofetuin, and unaffected by mannose. [125I]-labeled sIgA binding to macrophages reached a plateau after 60 min, was dependent on the number of macrophages in culture, and was specifically inhibited by unlabeled sIgA. Incubation of macrophage monolayers with increasing concentrations of sIgA-anti-IgA immune complexes resulted in a progressive increase in the oxidative burst and increased secretion of prostaglandins. These studies indicate that human milk macrophages have a receptor for sIgA and that activation of these macrophages may occur via these receptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Asialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Fetuins,
http://linkedlifedata.com/resource/pubmed/chemical/Galactose,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/IgA, secretory receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A, Secretory,
http://linkedlifedata.com/resource/pubmed/chemical/Mannose,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Fc,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Fetoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/asialofetuin
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0031-3998
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
429-34
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1716755-Asialoglycoproteins,
pubmed-meshheading:1716755-Dinoprostone,
pubmed-meshheading:1716755-Female,
pubmed-meshheading:1716755-Fetuins,
pubmed-meshheading:1716755-Galactose,
pubmed-meshheading:1716755-Humans,
pubmed-meshheading:1716755-Hydrogen Peroxide,
pubmed-meshheading:1716755-Immunoglobulin A, Secretory,
pubmed-meshheading:1716755-Macrophage Activation,
pubmed-meshheading:1716755-Macrophages,
pubmed-meshheading:1716755-Mannose,
pubmed-meshheading:1716755-Milk, Human,
pubmed-meshheading:1716755-Receptors, Fc,
pubmed-meshheading:1716755-Receptors, Immunologic,
pubmed-meshheading:1716755-Rosette Formation,
pubmed-meshheading:1716755-alpha-Fetoproteins
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pubmed:year |
1991
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pubmed:articleTitle |
Identification of a secretory IgA receptor on breast-milk macrophages: evidence for specific activation via these receptors.
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pubmed:affiliation |
Samuel Jared Kushnick Pediatric Immunology Laboratory, Department of Pediatrics, Sheba Medical Center Tel Aviv, Israel.
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pubmed:publicationType |
Journal Article
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