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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-3-26
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pubmed:databankReference |
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pubmed:abstractText |
Systemic sclerosis (SSc) is a connective tissue disorder characterized by early generalized microangiopathy with disturbed angiogenesis. Endoglin gene (ENG) encodes a transmembrane glycoprotein which acts as an accessory receptor for the transforming growth factor-beta (TGF-beta) superfamily, and is crucial for maintaining vascular integrity. A 6-base insertion in intron 7 (6bINS) of ENG has been reported to be associated with microvascular disturbance.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1462-0324
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pubmed:author |
pubmed-author:AllanoreYY,
pubmed-author:BoileauCC,
pubmed-author:CabaneJJ,
pubmed-author:GuillevinLL,
pubmed-author:HachullaEE,
pubmed-author:JunienCC,
pubmed-author:KahanAA,
pubmed-author:MeyerOO,
pubmed-author:MouthonLL,
pubmed-author:SibiliaJJ,
pubmed-author:WipffJJ
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
622-5
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pubmed:dateRevised |
2007-9-6
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pubmed:meshHeading |
pubmed-meshheading:17166870-Adult,
pubmed-meshheading:17166870-Aged,
pubmed-meshheading:17166870-Aged, 80 and over,
pubmed-meshheading:17166870-Antigens, CD,
pubmed-meshheading:17166870-Base Sequence,
pubmed-meshheading:17166870-Female,
pubmed-meshheading:17166870-Gene Frequency,
pubmed-meshheading:17166870-Genotype,
pubmed-meshheading:17166870-Humans,
pubmed-meshheading:17166870-Hypertension, Pulmonary,
pubmed-meshheading:17166870-Male,
pubmed-meshheading:17166870-Middle Aged,
pubmed-meshheading:17166870-Molecular Sequence Data,
pubmed-meshheading:17166870-Polymorphism, Genetic,
pubmed-meshheading:17166870-Receptors, Cell Surface,
pubmed-meshheading:17166870-Scleroderma, Systemic
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pubmed:year |
2007
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pubmed:articleTitle |
Association between an endoglin gene polymorphism and systemic sclerosis-related pulmonary arterial hypertension.
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pubmed:affiliation |
René Descartes University, Medical Faculty, Rheumatology A Department, Cochin Hospital, AP-HP, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
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