| pubmed-article:1716574 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1716574 | lifeskim:mentions | umls-concept:C0032176 | lld:lifeskim |
| pubmed-article:1716574 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:1716574 | lifeskim:mentions | umls-concept:C1517312 | lld:lifeskim |
| pubmed-article:1716574 | lifeskim:mentions | umls-concept:C0058381 | lld:lifeskim |
| pubmed-article:1716574 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1716574 | pubmed:dateCreated | 1991-10-24 | lld:pubmed |
| pubmed-article:1716574 | pubmed:abstractText | Diphenylene iodonium is an inhibitor of the enzyme NADPH-oxidase and prevents the generation of oxygen-derived free radicals in neutrophils (Cross and Jones, 1986). Here we show that diphenylene iodonium (0.25-2 microM) inhibited, according to the dose, thrombin-induced platelet-aggregation in human washed platelets and ADP-induced platelet aggregation in platelet-rich plasma. At the concentrations which inhibited platelet aggregation diphenylene iodonium did not alter platelet concentrations of cAMP or cGMP but enhanced the anti-platelet activity of iloprost, sodium nitroprusside or cultured endothelial cells. These findings highlight the importance of free radicals as platelet pro-aggregatory agents. | lld:pubmed |
| pubmed-article:1716574 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1716574 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716574 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1716574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1716574 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1716574 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:1716574 | pubmed:issn | 0014-2999 | lld:pubmed |
| pubmed-article:1716574 | pubmed:author | pubmed-author:MooreAA | lld:pubmed |
| pubmed-article:1716574 | pubmed:author | pubmed-author:WilloughbyDD | lld:pubmed |
| pubmed-article:1716574 | pubmed:author | pubmed-author:VaneJJ | lld:pubmed |
| pubmed-article:1716574 | pubmed:author | pubmed-author:MollaceVV | lld:pubmed |
| pubmed-article:1716574 | pubmed:author | pubmed-author:SalveminiDD | lld:pubmed |
| pubmed-article:1716574 | pubmed:author | pubmed-author:RadziszewskiW... | lld:pubmed |
| pubmed-article:1716574 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1716574 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:1716574 | pubmed:volume | 199 | lld:pubmed |
| pubmed-article:1716574 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1716574 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1716574 | pubmed:pagination | 15-8 | lld:pubmed |
| pubmed-article:1716574 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1716574 | pubmed:meshHeading | pubmed-meshheading:1716574-... | lld:pubmed |
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| pubmed-article:1716574 | pubmed:meshHeading | pubmed-meshheading:1716574-... | lld:pubmed |
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| pubmed-article:1716574 | pubmed:meshHeading | pubmed-meshheading:1716574-... | lld:pubmed |
| pubmed-article:1716574 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1716574 | pubmed:articleTitle | Diphenylene iodonium, an inhibitor of free radical formation, inhibits platelet aggregation. | lld:pubmed |
| pubmed-article:1716574 | pubmed:affiliation | William Harvey Research Institute, St. Bartholomew's Medical College, London, U.K. | lld:pubmed |
| pubmed-article:1716574 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1716574 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1716574 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1716574 | lld:pubmed |
