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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-10-24
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pubmed:abstractText |
Diphenylene iodonium is an inhibitor of the enzyme NADPH-oxidase and prevents the generation of oxygen-derived free radicals in neutrophils (Cross and Jones, 1986). Here we show that diphenylene iodonium (0.25-2 microM) inhibited, according to the dose, thrombin-induced platelet-aggregation in human washed platelets and ADP-induced platelet aggregation in platelet-rich plasma. At the concentrations which inhibited platelet aggregation diphenylene iodonium did not alter platelet concentrations of cAMP or cGMP but enhanced the anti-platelet activity of iloprost, sodium nitroprusside or cultured endothelial cells. These findings highlight the importance of free radicals as platelet pro-aggregatory agents.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Diphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Biphenyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radicals,
http://linkedlifedata.com/resource/pubmed/chemical/Iloprost,
http://linkedlifedata.com/resource/pubmed/chemical/NADH, NADPH Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroprusside,
http://linkedlifedata.com/resource/pubmed/chemical/Onium Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Aggregation Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Thrombin,
http://linkedlifedata.com/resource/pubmed/chemical/diphenyliodonium
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
199
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1716574-Adenosine Diphosphate,
pubmed-meshheading:1716574-Biphenyl Compounds,
pubmed-meshheading:1716574-Cyclic AMP,
pubmed-meshheading:1716574-Cyclic GMP,
pubmed-meshheading:1716574-Endothelium, Vascular,
pubmed-meshheading:1716574-Free Radicals,
pubmed-meshheading:1716574-Humans,
pubmed-meshheading:1716574-Iloprost,
pubmed-meshheading:1716574-Leukocytes,
pubmed-meshheading:1716574-NADH, NADPH Oxidoreductases,
pubmed-meshheading:1716574-Nitroprusside,
pubmed-meshheading:1716574-Onium Compounds,
pubmed-meshheading:1716574-Platelet Aggregation,
pubmed-meshheading:1716574-Platelet Aggregation Inhibitors,
pubmed-meshheading:1716574-Thrombin
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pubmed:year |
1991
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pubmed:articleTitle |
Diphenylene iodonium, an inhibitor of free radical formation, inhibits platelet aggregation.
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pubmed:affiliation |
William Harvey Research Institute, St. Bartholomew's Medical College, London, U.K.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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