Source:http://linkedlifedata.com/resource/pubmed/id/17165084
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2007-7-19
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| pubmed:abstractText |
Dihydropyrimidine dehydrogenase (DPD) enzyme is responsible for the elimination of approximately 80% of administered dose of 5-FU. DPD deficiency has been associated with severe 5-FU toxicity. Syndrome of DPD deficiency manifests as diarrhea, stomatitis, mucositis, and neurotoxicity and in some cases death. This is a true pharmacogenetic syndrome, with symptoms being unrecognizable until exposure to the drug.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0344-5704
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
60
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
503-7
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:17165084-Adenocarcinoma,
pubmed-meshheading:17165084-Aged,
pubmed-meshheading:17165084-Dihydrouracil Dehydrogenase (NADP),
pubmed-meshheading:17165084-Fatal Outcome,
pubmed-meshheading:17165084-Fluorouracil,
pubmed-meshheading:17165084-Humans,
pubmed-meshheading:17165084-Male,
pubmed-meshheading:17165084-Mutation,
pubmed-meshheading:17165084-Pancreatic Neoplasms,
pubmed-meshheading:17165084-Sequence Analysis, DNA
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
DPYD*2A mutation: the most common mutation associated with DPD deficiency.
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| pubmed:affiliation |
Yale University School of Medicine, Section of Medical Oncology, 333 Cedar Street; FMP 116, New Haven, CT 06520, USA. wasif.saif@yale.edu
|
| pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, N.I.H., Extramural
|