Source:http://linkedlifedata.com/resource/pubmed/id/17164441
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2007-4-2
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| pubmed:abstractText |
Adiponectin and its receptors play an important role in energy homeostasis and insulin resistance, but their regulation remains to be fully elucidated. We hypothesized that high-fat diet would decrease adiponectin but increase adiponectin receptor (AdipoR1 and AdipoR2) expression in diet-induced obesity (DIO)-prone C57BL/6J and DIO-resistant A/J mice. We found that circulating adiponectin and adiponectin expression in white adipose tissue are higher at baseline in C57BL/6J mice compared with A/J mice. Circulating adiponectin increases at 10 wk but decreases at 18 wk in response to advancing age and high-fat feeding. However, adiponectin levels corrected for visceral fat mass and adiponectin mRNA expression in WAT are affected by high-fat feeding only, with both being decreased after 10 wk in C57BL/6J mice. Muscle AdipoR1 expression in both C57BL/6J and A/J mice and liver adipoR1 expression in C57BL/6J mice increase at 18 wk of age. High-fat feeding increases both AdipoR1 and AdipoR2 expression in liver in both strains of mice and increases muscle AdipoR1 expression in C57BL/6J mice after 18 wk. Thus advanced age and high-fat feeding, both of which are factors that predispose humans to obesity and insulin resistance, are associated with decreasing adiponectin and increasing AdipoR1 and/or AdipoR2 levels.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adiponectin,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adiponectin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/adiponectin receptor 1, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/adiponectin receptor 2, mouse
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0193-1849
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
292
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
E1079-86
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:17164441-Adiponectin,
pubmed-meshheading:17164441-Adipose Tissue,
pubmed-meshheading:17164441-Aging,
pubmed-meshheading:17164441-Animals,
pubmed-meshheading:17164441-Blood Glucose,
pubmed-meshheading:17164441-Body Composition,
pubmed-meshheading:17164441-Body Weight,
pubmed-meshheading:17164441-Dietary Fats,
pubmed-meshheading:17164441-Disease Susceptibility,
pubmed-meshheading:17164441-Insulin,
pubmed-meshheading:17164441-Leptin,
pubmed-meshheading:17164441-Mice,
pubmed-meshheading:17164441-Mice, Inbred A,
pubmed-meshheading:17164441-Mice, Inbred C57BL,
pubmed-meshheading:17164441-Muscle, Skeletal,
pubmed-meshheading:17164441-Obesity,
pubmed-meshheading:17164441-RNA, Messenger,
pubmed-meshheading:17164441-Receptors, Adiponectin,
pubmed-meshheading:17164441-Receptors, Cell Surface
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| pubmed:year |
2007
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| pubmed:articleTitle |
Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice.
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| pubmed:affiliation |
Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Ave., Boston, MA 02215, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|