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rdf:type |
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lifeskim:mentions |
umls-concept:C0003692,
umls-concept:C0018270,
umls-concept:C0033572,
umls-concept:C0079427,
umls-concept:C0086418,
umls-concept:C0205245,
umls-concept:C0231337,
umls-concept:C0456389,
umls-concept:C0851285,
umls-concept:C1325410,
umls-concept:C1326057
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pubmed:issue |
1-4
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pubmed:dateCreated |
2006-12-13
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pubmed:abstractText |
15-Lipoxygenase 2 (15-LOX2) is the major mammalian lipoxygenase expressed in normal human adult prostate and its expression is decreased or lost in high-grade prostate intraepithelial neoplasia (HGPIN) and prostate cancer (PCa). Our recent work has demonstrated that (1) 15-LOX2 has multiple alternatively spliced isoforms and is a negative cell-cycle regulator in normal human prostate (NHP) epithelial cells; (2) 15-LOX2 in NHP cells is positively regulated by Sp1 and negatively regulated by Sp3; (3) 15-LOX2 in NHP cells may be partially involved in cell differentiation; (4) 15-LOX2 is cell-autonomously upregulated in cultured NHP cells and its induction is associated with NHP cell senescence; and (5) 15-LOX2 is a functional prostate tumor suppressor. Here we summarize these new findings to provide a concise view of the potential biological functions of 15-LOX2 in NHP cells and of its deregulation in PCa development.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/15-hydroxy-5,8,11,13-eicosatetraenoi...,
http://linkedlifedata.com/resource/pubmed/chemical/ALOX15B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonate 15-Lipoxygenase,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyeicosatetraenoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Androgen,
http://linkedlifedata.com/resource/pubmed/chemical/SP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Sp1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Sp3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1098-8823
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
135-46
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17164141-Adult,
pubmed-meshheading:17164141-Alternative Splicing,
pubmed-meshheading:17164141-Arachidonate 15-Lipoxygenase,
pubmed-meshheading:17164141-Cadherins,
pubmed-meshheading:17164141-Cell Aging,
pubmed-meshheading:17164141-Cell Cycle Proteins,
pubmed-meshheading:17164141-Cell Differentiation,
pubmed-meshheading:17164141-Cell Enlargement,
pubmed-meshheading:17164141-Epithelial Cells,
pubmed-meshheading:17164141-Gene Expression,
pubmed-meshheading:17164141-Humans,
pubmed-meshheading:17164141-Hydroxyeicosatetraenoic Acids,
pubmed-meshheading:17164141-Male,
pubmed-meshheading:17164141-Prostate,
pubmed-meshheading:17164141-Prostatic Neoplasms,
pubmed-meshheading:17164141-Receptors, Androgen,
pubmed-meshheading:17164141-Sp1 Transcription Factor,
pubmed-meshheading:17164141-Sp3 Transcription Factor,
pubmed-meshheading:17164141-Tumor Suppressor Proteins
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pubmed:year |
2007
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pubmed:articleTitle |
15-lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size).
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pubmed:affiliation |
Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park-Research Division, 1808 Park Rd. 1C, Smithville, TX 78957, United States. dtang@mdanderson.org
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Review,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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