Linked Life Data

17163355

Source:http://linkedlifedata.com/resource/pubmed/id/17163355

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2006-12-13
pubmed:abstractText
Neonatal hypoxia is a common condition that elicits a coordinated endocrine response. In the neonatal rat, hypoxia induces an ACTH-independent increase in corticosterone which can be partially blocked by chemical sympathectomy. The present study sought to characterize the effects of sympathectomy on the adrenal lipid profile, since previous work suggested that augmented plasma corticosterone during hypoxia may be due to changes in adrenal lipid metabolism. Newborn rats were exposed to normoxia or hypoxia from birth to seven days of age, and guanethidine was used to produce the sympathectomy. Plasma epinephrine and norepinephrine were not significantly affected by hypoxia, while guanethidine decreased plasma norepinephrine in normoxic and hypoxic pups. Hypoxia alone increased the concentration of cholesterol esters in the adrenal gland; this increase was due to increases in cholesterol ester-associated oleic (18:1n9), docosahexaenoic (22:6n3), arachidonic (20:4n6), and adrenic (22:4n6) acids. Hypoxia also increased diglyceride-associated adrenic acid. Guanethidine treatment attenuated the hypoxia-induced increase in cholesterol ester-bound arachidonic and adrenic acids. Guanethidine also decreased saturated fatty acid concentrations and increased n3 fatty acid-enriched triglycerides. The results support the idea that the ACTH-independent corticosterone response to hypoxia in the neonatal rat is mediated by specific, sympathetically driven alterations in the adrenal lipid profile.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17163355-10385408, http://linkedlifedata.com/resource/pubmed/commentcorrection/17163355-11489878, http://linkedlifedata.com/resource/pubmed/commentcorrection/17163355-12064968, http://linkedlifedata.com/resource/pubmed/commentcorrection/17163355-12401879, http://linkedlifedata.com/resource/pubmed/commentcorrection/17163355-14525916, http://linkedlifedata.com/resource/pubmed/commentcorrection/17163355-14709419, http://linkedlifedata.com/resource/pubmed/commentcorrection/17163355-2178102, http://linkedlifedata.com/resource/pubmed/commentcorrection/17163355-3315406, http://linkedlifedata.com/resource/pubmed/commentcorrection/17163355-7106123, http://linkedlifedata.com/resource/pubmed/commentcorrection/17163355-7266082, http://linkedlifedata.com/resource/pubmed/commentcorrection/17163355-7686060, http://linkedlifedata.com/resource/pubmed/commentcorrection/17163355-8558480, http://linkedlifedata.com/resource/pubmed/commentcorrection/17163355-8952593, http://linkedlifedata.com/resource/pubmed/commentcorrection/17163355-9781323, http://linkedlifedata.com/resource/pubmed/commentcorrection/17163355-9804559, http://linkedlifedata.com/resource/pubmed/commentcorrection/17163355-9888594
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0018-5043
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
807-11
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Adrenal lipid profiles of chemically sympathectomized normoxic and hypoxic neonatal rats.
pubmed:affiliation
Endocrine Research Laboratory, St. Luke's Medical Center, Milwaukee, WI 53215, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural