|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017638,
umls-concept:C0035820,
umls-concept:C0040053,
umls-concept:C0072980,
umls-concept:C0205420,
umls-concept:C0332293,
umls-concept:C0520484,
umls-concept:C0871261,
umls-concept:C1522449,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1822997,
umls-concept:C1979893,
umls-concept:C2911692
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2007-1-22
|
|
pubmed:abstractText |
Rapamycin, a highly specific mTOR inhibitor, has shown anti-proliferative and anti-angiogenic properties, as well as an enhancement in tumour growth delay when used in combination with radiation in mouse xenograft models. Our goal was to determine if rapamycin can also have a positive effect on the local tumour control achieved by radiotherapy.
|
|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0167-8140
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
82
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
96-104
|
|
pubmed:meshHeading |
pubmed-meshheading:17161482-Animals,
pubmed-meshheading:17161482-Antibiotics, Antineoplastic,
pubmed-meshheading:17161482-Cell Hypoxia,
pubmed-meshheading:17161482-Cell Line, Tumor,
pubmed-meshheading:17161482-Combined Modality Therapy,
pubmed-meshheading:17161482-Dose Fractionation,
pubmed-meshheading:17161482-Glioblastoma,
pubmed-meshheading:17161482-Mice,
pubmed-meshheading:17161482-Mice, Nude,
pubmed-meshheading:17161482-Neoplasm Transplantation,
pubmed-meshheading:17161482-Radiotherapy Dosage,
pubmed-meshheading:17161482-Signal Transduction,
pubmed-meshheading:17161482-Sirolimus,
pubmed-meshheading:17161482-Thrombosis,
pubmed-meshheading:17161482-Transplantation, Heterologous
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Response of U87 glioma xenografts treated with concurrent rapamycin and fractionated radiotherapy: possible role for thrombosis.
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|
pubmed:affiliation |
Maastricht Radiation Oncology (Maastro), GROW Research Institute, University Maastricht, Maastricht, The Netherlands.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
