Basic fibroblast growth factor (FGF2) plays a crucial role during the development of the cerebral cortex. Mice with a knockout of the FGF2 gene have a reduced number of glutamatergic neurons within the deep layers of the cerebral cortex.
Reduction of corticostriatal glutamatergic fibers in basic fibroblast growth factor deficient mice is associated with hyperactivity and enhanced dopaminergic transmission.
Department of Neuroscience B.B. Brodie, Center for Excellence in Neurobiology of Dependence, University of Cagliari, Cittadella Universitaria, Monserrato, Italy.