Linked Life Data

17161237

Source:http://linkedlifedata.com/resource/pubmed/id/17161237

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-12-12
pubmed:abstractText
Pancreatic preservation is an important part of diabetes management that may occur with improved peripheral insulin sensitivity and attenuated low-grade adipose tissue inflammation. The objective of the current study was to determine the response of obese, insulin-resistant fa/fa Zucker rats vs lean controls to dietary conjugated linoleic acid (CLA) supplementation with respect to pancreatic islet size, insulin resistance, and markers of inflammation and adipose glucose uptake. Six-week-old fa/fa and lean Zucker rats (n = 20 per genotype) were fed either a 1.5% CLA mixture or control diet for 8 weeks. Oral glucose tolerance testing was conducted at 7.5 weeks. Fasting serum haptoglobin, insulin, and C-peptide were assayed, and select messenger RNA (mRNA) and protein markers of inflammation and glucose metabolism were measured in adipose and liver tissues. CLA-fed fa/fa Zucker rats had smaller islet cell size, improved oral glucose tolerance and insulinemia, and attenuated serum haptoglobin levels compared with control-fed fa/fa Zucker rats, despite no differences in body weight and a slightly higher visceral adipose mass. CLA did not alter insulin sensitivity or islet size in lean Zucker rats. The CLA-fed fa/fa rats also had greater adipose glucose transporter-4 mRNA and less adipose tumor necrosis factor alpha mRNA and protein compared with control-fed fa/fa rats. In contrast, other markers of inflammation and glucose metabolism including adipose macrophage inflammatory factor, macrophage inflammatory protein-2, and liver pyruvate carboxylase and pyruvate dehydrogenase kinase 4 were not significantly changed. These results suggest that CLA supplementation preserved pancreatic function in conjunction with improved peripheral glucose use and reduced inflammation in fa/fa Zucker rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0026-0495
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
142-51
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:17161237-Adipose Tissue, pubmed-meshheading:17161237-Animals, pubmed-meshheading:17161237-Blotting, Western, pubmed-meshheading:17161237-C-Reactive Protein, pubmed-meshheading:17161237-Dietary Fats, Unsaturated, pubmed-meshheading:17161237-Glucose Tolerance Test, pubmed-meshheading:17161237-Haptoglobins, pubmed-meshheading:17161237-Insulin, pubmed-meshheading:17161237-Insulin Resistance, pubmed-meshheading:17161237-Insulin-Secreting Cells, pubmed-meshheading:17161237-Linoleic Acids, Conjugated, pubmed-meshheading:17161237-Liver, pubmed-meshheading:17161237-Organ Size, pubmed-meshheading:17161237-Pancreas, pubmed-meshheading:17161237-Protein Kinases, pubmed-meshheading:17161237-Protein-Serine-Threonine Kinases, pubmed-meshheading:17161237-Pyruvate Carboxylase, pubmed-meshheading:17161237-Rats, pubmed-meshheading:17161237-Rats, Zucker, pubmed-meshheading:17161237-Reverse Transcriptase Polymerase Chain Reaction
pubmed:year
2007
pubmed:articleTitle
Dietary conjugated linoleic acid preserves pancreatic function and reduces inflammatory markers in obese, insulin-resistant rats.
pubmed:affiliation
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada R3T 2N2.
pubmed:publicationType
Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't