Linked Life Data

17160647

Source:http://linkedlifedata.com/resource/pubmed/id/17160647

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-12-22
pubmed:databankReference
pubmed:abstractText
All eukaryotes express mitogen-activated protein kinases (MAPKs) that govern diverse cellular processes including proliferation, differentiation, and survival. Even though these proteins are highly conserved throughout nature, MAPKs from closely related species often possess distinct signature sequences, making them well suited as drug discovery targets. Based on the central amino acid in the TXY dual phosphorylation loop, mammalian MAPKs are classified as extracellular signal-regulated kinases (ERKs), c-Jun amino-terminal kinases (JNKs), or p38 stress-response MAPKs. The presence of MAPKs in nonmetazoan eukaryotes suggests significant evolutionary conservation of these important signalling pathways. We recently cloned a novel stress-response MAPK gene (tgMAPK1) from Toxoplasma gondii, an obligate intracellular human parasite that can cause life-threatening infections in immunocompromised patients, and we now present data on a second T. gondii MAPK gene (tgMAPK2) that we cloned. We show that tgMAPK1 and tgMAPK2 are members of two distinct and previously unknown protozoan MAPK subfamilies that we have named pzMAPKl/pzMAPK3 and pzMAPK2. Our phylogenetic analysis of a collection of protozoan and metazoan MAPK genes in relation to ERK8-like genes demonstrates that an ERK8-like family, which includes the pzMAPK2 subfamily, is represented across a large variety of eukaryotic kingdoms and is evolutionarily very distant from other MAPK families.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-2844
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4-14
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:17160647-Amino Acid Sequence, pubmed-meshheading:17160647-Animals, pubmed-meshheading:17160647-Base Sequence, pubmed-meshheading:17160647-Cloning, Molecular, pubmed-meshheading:17160647-Evolution, Molecular, pubmed-meshheading:17160647-Gene Expression Regulation, Enzymologic, pubmed-meshheading:17160647-Mitogen-Activated Protein Kinase 1, pubmed-meshheading:17160647-Mitogen-Activated Protein Kinase 3, pubmed-meshheading:17160647-Mitogen-Activated Protein Kinases, pubmed-meshheading:17160647-Molecular Sequence Data, pubmed-meshheading:17160647-Multigene Family, pubmed-meshheading:17160647-Phosphorylation, pubmed-meshheading:17160647-Phylogeny, pubmed-meshheading:17160647-Protozoan Proteins, pubmed-meshheading:17160647-Sequence Homology, Amino Acid, pubmed-meshheading:17160647-Toxoplasma
pubmed:year
2007
pubmed:articleTitle
Toxoplasma gondii expresses two mitogen-activated protein kinase genes that represent distinct protozoan subfamilies.
pubmed:affiliation
Tulane University, Department of Mathematics, 6823 St. Charles Avenue, New Orleans, LA 70118, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural