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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-2-5
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pubmed:abstractText |
Untreated Toxoplasma gondii-infections are often fatal in AIDS-patients. Many African countries struck hard by HIV/AIDS exhibit a high seroprevalence of T. gondii, but the rate of reactivated parasites among African HIV-patients has never previously been determined. In this study, IgG-agglutination and PCR was used to analyse blood samples from 130 HIV-positive patients in Uganda. Anti-T. gondii antibodies were detected in 54% of the patients while 23% had parasites in the peripheral blood, which indicates active infection. Genotyping of the SAG2-locus revealed the type II allele for most disease-causing strains (60%), but all three SAG2-types was represented in our study population. Furthermore, one sample appeared to harbour a recombinant strain, with SAG2 type II but the type I-allele at the BTUB-gene. This study emphasizes the high prevalence of toxoplasmosis among Ugandan HIV-patients and also suggests that recombinant or atypical strains may be present in this part of the world.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0001-706X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
218-22
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pubmed:meshHeading |
pubmed-meshheading:17157795-Adult,
pubmed-meshheading:17157795-Alleles,
pubmed-meshheading:17157795-Animals,
pubmed-meshheading:17157795-Antibodies, Protozoan,
pubmed-meshheading:17157795-Antigens, Protozoan,
pubmed-meshheading:17157795-DNA, Protozoan,
pubmed-meshheading:17157795-Female,
pubmed-meshheading:17157795-Genes, Protozoan,
pubmed-meshheading:17157795-HIV,
pubmed-meshheading:17157795-HIV Infections,
pubmed-meshheading:17157795-Humans,
pubmed-meshheading:17157795-Immunoglobulin G,
pubmed-meshheading:17157795-Male,
pubmed-meshheading:17157795-Middle Aged,
pubmed-meshheading:17157795-Parasitemia,
pubmed-meshheading:17157795-Polymerase Chain Reaction,
pubmed-meshheading:17157795-Protozoan Proteins,
pubmed-meshheading:17157795-Recurrence,
pubmed-meshheading:17157795-Risk Factors,
pubmed-meshheading:17157795-Seroepidemiologic Studies,
pubmed-meshheading:17157795-Species Specificity,
pubmed-meshheading:17157795-Toxoplasma,
pubmed-meshheading:17157795-Toxoplasmosis,
pubmed-meshheading:17157795-Uganda
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pubmed:year |
2006
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pubmed:articleTitle |
Prevalence of latent and reactivated Toxoplasma gondii parasites in HIV-patients from Uganda.
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pubmed:affiliation |
Department of Parasitology, Mycology and Water & Environmental Microbiology, Swedish Institute for Infectious Disease Control, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article
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