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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-1-26
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pubmed:abstractText |
The present study determined if chronic simvastatin administration in vivo would provide neuroprotection in brain cells isolated from guinea pigs after challenge with the Bcl-2 inhibitor HA 14-1 or the NO donor sodium nitroprusside (SNP). Bcl-2 levels were significantly increased in brains of simvastatin-treated guinea pigs while levels of the pro-apoptotic protein Bax were significantly reduced. The ratio of Bax/Bcl-2, being a critical factor of the apoptotic state of cells, was significantly reduced in simvastatin-treated animals. Cholesterol levels in the brain remained unchanged in the simvastatin group. Brain cells isolated from simvastatin-treated guinea pigs were significantly less vulnerable to mitochondrial dysfunction and caspase-activation. These results provide new insight into potential mechanisms for the protective actions of statins within the CNS where programmed cell death has been implicated.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0969-9961
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
438-45
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pubmed:dateRevised |
2008-6-5
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pubmed:meshHeading |
pubmed-meshheading:17157514-Animals,
pubmed-meshheading:17157514-Apoptosis,
pubmed-meshheading:17157514-Benzopyrans,
pubmed-meshheading:17157514-Brain,
pubmed-meshheading:17157514-Caspases,
pubmed-meshheading:17157514-Cells, Cultured,
pubmed-meshheading:17157514-Drug Administration Schedule,
pubmed-meshheading:17157514-Enzyme Inhibitors,
pubmed-meshheading:17157514-Guinea Pigs,
pubmed-meshheading:17157514-Male,
pubmed-meshheading:17157514-Mitochondria,
pubmed-meshheading:17157514-Neurons,
pubmed-meshheading:17157514-Neuroprotective Agents,
pubmed-meshheading:17157514-Nitric Oxide Donors,
pubmed-meshheading:17157514-Nitriles,
pubmed-meshheading:17157514-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:17157514-Simvastatin,
pubmed-meshheading:17157514-Up-Regulation,
pubmed-meshheading:17157514-bcl-2-Associated X Protein
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pubmed:year |
2007
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pubmed:articleTitle |
Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment.
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pubmed:affiliation |
Department of Pharmacology, ZAFES, Biocenter Niederursel, N260 Max-von-Laue Str. 9, University of Frankfurt, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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