|
rdf:type |
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|
lifeskim:mentions |
umls-concept:C0007590,
umls-concept:C0014442,
umls-concept:C0035647,
umls-concept:C0205208,
umls-concept:C0205224,
umls-concept:C0220781,
umls-concept:C0243077,
umls-concept:C0279516,
umls-concept:C0456387,
umls-concept:C1883254,
umls-concept:C2348042
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|
pubmed:issue |
3
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|
pubmed:dateCreated |
2007-1-8
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|
pubmed:abstractText |
As a model system for designing new inhibitors of bacterial cell division, we studied the essential and highly conserved FtsZ GTPase from Pseudomonas aeruginosa. A collection of GTP analogues were prepared using the solid-phase parallel synthesis approach. The synthesized GTP analogues inhibited the GTPase activity of FtsZ with IC(50) values between 450microM and 2.6mM, and 5 compounds inhibited Staphylococcus aureus growth in a biological assay. The FtsZ spectrophotometric assay developed for screening of synthesized compounds is the first step in identification of antibacterials targeting the bacterial cell division essential proteins.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
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pubmed:status |
MEDLINE
|
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pubmed:month |
Feb
|
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pubmed:issn |
0968-0896
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1330-40
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pubmed:meshHeading |
|
|
pubmed:year |
2007
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pubmed:articleTitle |
Parallel solid synthesis of inhibitors of the essential cell division FtsZ enzyme as a new potential class of antibacterials.
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|
pubmed:affiliation |
CREFSIP, Département de Biologie Médicale, Faculté de médecine, Université Laval, Sainte-Foy, Que., Canada G1K 7P4.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
