|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0002085,
umls-concept:C0003211,
umls-concept:C0017431,
umls-concept:C0027778,
umls-concept:C0030920,
umls-concept:C0043157,
umls-concept:C0205419,
umls-concept:C0220938,
umls-concept:C0596130,
umls-concept:C0608437,
umls-concept:C0681850,
umls-concept:C1524063,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C2349001,
umls-concept:C2697811
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2006-12-12
|
|
pubmed:abstractText |
The most common serious adverse effects (AEs) associated with NSAID therapy are bleeding and perforated gastroduodenal ulcers. These AEs are dose related, and reduced oral clearance of NSAIDs associated with polymorphisms of cytochrome P450 (CYP) would, theoretically, increase the risk for AEs.
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|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0149-2918
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
28
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1670-6
|
|
pubmed:meshHeading |
pubmed-meshheading:17157122-Adult,
pubmed-meshheading:17157122-Aged,
pubmed-meshheading:17157122-Aged, 80 and over,
pubmed-meshheading:17157122-Alleles,
pubmed-meshheading:17157122-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:17157122-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:17157122-Cohort Studies,
pubmed-meshheading:17157122-Duodenal Ulcer,
pubmed-meshheading:17157122-European Continental Ancestry Group,
pubmed-meshheading:17157122-Female,
pubmed-meshheading:17157122-Humans,
pubmed-meshheading:17157122-Male,
pubmed-meshheading:17157122-Middle Aged,
pubmed-meshheading:17157122-Netherlands,
pubmed-meshheading:17157122-Stomach Ulcer
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Allele variants of the cytochrome P450 2C9 genotype in white subjects from The Netherlands with serious gastroduodenal ulcers attributable to the use of NSAIDs.
|
|
pubmed:affiliation |
Department of Rheumatolog and Clinical Immunoloy, Medisch Spectrum Twente Hospital, University of Twente, Enschede, The Netherlands. H.Vonkeman@ziekenhuis-mst.nl
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pubmed:publicationType |
Journal Article
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