Linked Life Data

17156698

Source:http://linkedlifedata.com/resource/pubmed/id/17156698

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2006-12-12
pubmed:abstractText
Damage or loss of inhibitory cortical gamma-aminobutyric acid (GABA)ergic interneurons is associated with impaired inhibitory control of neocortical pyramidal cells, leading to hyperexcitability and epileptogenesis. The calcium binding proteins parvalbumin and calbindin-D(28k) are expressed in subpopulations of GABAergic local circuit neurons in the neocortex and can serve as neuronotypic markers. Parvalbumin and calbindin-D(28k) facilitate the neuron's ability to sustain firing and provide neuroprotection. The goal of this study was to assess the hitherto unknown status of inhibitory interneurons in cortical tubers of human tuberous sclerosis complex. Surgically excised cortical tubers from three patients with tuberous sclerosis complex were evaluated immunohistochemically with antibodies to parvalbumin and calbindin-D(28k). Cortical specimens from young patients with intractable seizures, including microdysgenesis (n = 3), postischemic cortical scarring (n = 1), porencephaly (n = 1), postictal gliosis (n = 3), and low-grade neuronal or glial tumors (n = 5), were also examined for comparison. In cortical tubers, calcium binding protein immunoreactivities (calbindin-D(28k) > parvalbumin) were present in medium- or large-size dysplastic neurons, whereas giant or ballooned cells were parvalbumin or calbindin-D(28k) negative. In microdysgenesis, a nearly normal number of parvalbumin-positive neurons and a decreased number of calbindin-D(28k)-positive neurons were present. In peritumoral but more so in gliotic cortex, a coordinate decrease of parvalbumin and calbindin-D(28k) immunoreactivities was present. Our findings indicate that the expression of parvalbumin or calbindin-D(28k) by subpopulations of dysplastic neurons in cortical tubers is aberrant and denotes dysfunctional inhibitory circuits inept for excitoprotection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0883-0738
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1058-63
pubmed:meshHeading
pubmed-meshheading:17156698-Adolescent, pubmed-meshheading:17156698-Adult, pubmed-meshheading:17156698-Biological Markers, pubmed-meshheading:17156698-Calcium, pubmed-meshheading:17156698-Calcium-Binding Protein, Vitamin D-Dependent, pubmed-meshheading:17156698-Calcium-Binding Proteins, pubmed-meshheading:17156698-Cerebral Cortex, pubmed-meshheading:17156698-Child, pubmed-meshheading:17156698-Child, Preschool, pubmed-meshheading:17156698-Cytoprotection, pubmed-meshheading:17156698-Dendrites, pubmed-meshheading:17156698-Epilepsy, pubmed-meshheading:17156698-Gliosis, pubmed-meshheading:17156698-Humans, pubmed-meshheading:17156698-Immunohistochemistry, pubmed-meshheading:17156698-Infant, pubmed-meshheading:17156698-Interneurons, pubmed-meshheading:17156698-Neural Inhibition, pubmed-meshheading:17156698-Neural Pathways, pubmed-meshheading:17156698-Parvalbumins, pubmed-meshheading:17156698-Tuberous Sclerosis, pubmed-meshheading:17156698-gamma-Aminobutyric Acid
pubmed:year
2006
pubmed:articleTitle
Anomalous inhibitory circuits in cortical tubers of human tuberous sclerosis complex associated with refractory epilepsy: aberrant expression of parvalbumin and calbindin-D28k in dysplastic cortex.
pubmed:affiliation
Department of Pediatrics, Drexel University College of Medicine, Section of Neurology, St. Christopher's Hospital for Children, Philadelphia, PA, USA. Ignacio.Valencia@drexelmed.edu
pubmed:publicationType
Journal Article