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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-2-26
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pubmed:abstractText |
Clotting factor (F) VIII is an independent risk factor for primary and recurrent venous thromboembolism (VTE). The causes for high plasma FVIII levels are not fully understood, but an involvement of genetic factors has been demonstrated. A multifunctional endocytic receptor, low-density lipoprotein receptor-related protein 1 (LRP1), mediates cellular uptake and subsequent degradation of FVIII and may contribute to variations in FVIII levels.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1538-7933
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
497-502
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17155964-Case-Control Studies,
pubmed-meshheading:17155964-Cytosine,
pubmed-meshheading:17155964-Factor VIII,
pubmed-meshheading:17155964-Female,
pubmed-meshheading:17155964-Gene Frequency,
pubmed-meshheading:17155964-Genetic Predisposition to Disease,
pubmed-meshheading:17155964-Genotype,
pubmed-meshheading:17155964-Heterozygote,
pubmed-meshheading:17155964-Humans,
pubmed-meshheading:17155964-Linear Models,
pubmed-meshheading:17155964-Low Density Lipoprotein Receptor-Related Protein-1,
pubmed-meshheading:17155964-Male,
pubmed-meshheading:17155964-Middle Aged,
pubmed-meshheading:17155964-Odds Ratio,
pubmed-meshheading:17155964-Polymorphism, Single Nucleotide,
pubmed-meshheading:17155964-Recurrence,
pubmed-meshheading:17155964-Risk Assessment,
pubmed-meshheading:17155964-Risk Factors,
pubmed-meshheading:17155964-Thromboembolism,
pubmed-meshheading:17155964-Thymine,
pubmed-meshheading:17155964-Venous Thrombosis
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pubmed:year |
2007
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pubmed:articleTitle |
Low-density lipoprotein receptor-related protein 1 polymorphism 663 C > T affects clotting factor VIII activity and increases the risk of venous thromboembolism.
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pubmed:affiliation |
Division of Haematology and Haemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
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pubmed:publicationType |
Journal Article
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