Linked Life Data

17154081

Source:http://linkedlifedata.com/resource/pubmed/id/17154081

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2006-12-12
pubmed:abstractText
Graves' disease is a well-known organ-specific autoimmune disease, in which stimulatory anti-thyrotropin (TSH) receptor antibodies cause hyperthyroidism and diffuse goiter. Several animal models of this disease have been established for the last decade using the living cells expressing TSH receptor or genetic immunization with the plasmid or adenovirus. Significant progresses on our understanding of the pathogenesis of this disease have been obtained from these models, which include (1) the pathological role of the TSH receptor cleavage, (2) antigen-presenting cells involving anti-TSH receptor immune response, (3) immune tolerance to TSH receptor, and (4) genetic and environmental factors involving the pathogenesis of this disease. Recent data on these topics are summarized in this review.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0047-1852
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2215-8
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
[Progress in the pathogenesis of Graves' disease: approaches from animal models].
pubmed:affiliation
Department of Medical Gene Technology, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University.
pubmed:publicationType
Journal Article, English Abstract, Review