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rdf:type |
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lifeskim:mentions |
umls-concept:C0017428,
umls-concept:C0035668,
umls-concept:C0086022,
umls-concept:C0205263,
umls-concept:C0301872,
umls-concept:C0332161,
umls-concept:C0332261,
umls-concept:C0442335,
umls-concept:C0546816,
umls-concept:C0598312,
umls-concept:C1515655,
umls-concept:C1623048,
umls-concept:C1705099
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pubmed:issue |
4
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pubmed:dateCreated |
2007-1-29
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pubmed:abstractText |
Live-attenuated vesicular stomatitis virus (VSV) vectors expressing foreign antigens induce potent immune responses and protect against viral diseases in animal models. Highly attenuated (VSV-CT1) or single-cycle VSV (VSVDeltaG) vectors induce immune responses lower than those generated by attenuated wild-type VSV vectors when given intranasally. We show here that reduced spread of the more highly attenuated or single-cycle vectors to other organs, including lymph nodes, correlates with the reduction in the immune responses. A reverse transcription, real-time PCR assay for VSV genomic RNA (gRNA) sequences showed long-term persistence of gRNA from replicating vectors in lymph nodes, long after viral clearance. Such persistence may be important for induction of potent immune responses by VSV vectors.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-10196265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-10775601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-11551502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-11602747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-11773406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-12163609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-12867646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-14990742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-15047809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-15308726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-15585086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-15937495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-16043204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-16227246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-17151119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-4309413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-7753828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-8289375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-8638411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-8638415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-9298897,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-9482726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17151110-9573234
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2078-82
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17151110-Animals,
pubmed-meshheading:17151110-Antibodies, Viral,
pubmed-meshheading:17151110-Antibody Specificity,
pubmed-meshheading:17151110-Genetic Vectors,
pubmed-meshheading:17151110-Immunization,
pubmed-meshheading:17151110-Injections, Intralymphatic,
pubmed-meshheading:17151110-Lymph Nodes,
pubmed-meshheading:17151110-Mice,
pubmed-meshheading:17151110-Mice, Inbred BALB C,
pubmed-meshheading:17151110-Neutralization Tests,
pubmed-meshheading:17151110-RNA, Viral,
pubmed-meshheading:17151110-Time Factors,
pubmed-meshheading:17151110-Vesicular stomatitis Indiana virus,
pubmed-meshheading:17151110-Virus Replication
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pubmed:year |
2007
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pubmed:articleTitle |
Replication and propagation of attenuated vesicular stomatitis virus vectors in vivo: vector spread correlates with induction of immune responses and persistence of genomic RNA.
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pubmed:affiliation |
Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06510, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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