Linked Life Data

17150893

Source:http://linkedlifedata.com/resource/pubmed/id/17150893

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
50
pubmed:dateCreated
2006-12-7
pubmed:abstractText
Base-modified nucleic acids are being evaluated for applications in biotechnology and as therapeutic agents. We found that bicyclic-C (biC), which is a cytosine derivative with a propene attached at the N(4) and C(5) atoms, increases the stability of DNA duplexes. To establish the conformational effects of biC on DNA and to obtain insight into the correlation between the structure and stability of biC-containing DNA duplexes, the crystal structure of [d(CGCGAATT x biC x GCG)](2) has been determined at 2.2 A resolution. The global and local conformations of the present biC-containing duplex and the native duplex are very similar. Only the base stacking interactions at the base pair steps containing the biC residues are significantly changed. This change in stacking area, however, explains the increased stability of biC-containing DNA duplexes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1746-8272
pubmed:author
pubmed:issnType
Electronic
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
213-4
pubmed:dateRevised
2007-9-19
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
X-Ray analyses of DNA duplexes stabilized by bicyclic-C residues.
pubmed:affiliation
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
pubmed:publicationType
Journal Article