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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-1-22
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pubmed:abstractText |
Maintaining a proper balance of metal concentrations is critical to the survival of bacteria. We have designed and synthesized a series of conjugates of metal chelators and efflux transporter substrates aimed at disrupting bacterial metal homeostasis to achieve bacterial killing. Biological studies showed that two of the compounds had very significant antimicrobial effect with an MIC value of 7.8 microg/mL against Gram-positive Bacillus subtilis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BrandtGaryG,
pubmed-author:Eric BallardCC,
pubmed-author:GaoXingmingX,
pubmed-author:KoKo-ChunKC,
pubmed-author:LouXinhuiX,
pubmed-author:LuChung-DarCD,
pubmed-author:TaiPhang CPC,
pubmed-author:WangBingheB,
pubmed-author:YangHsiuchinH,
pubmed-author:ZhangYanlingY,
pubmed-author:ZhengShi-LongSL
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
707-11
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pubmed:meshHeading |
pubmed-meshheading:17150357-Anti-Bacterial Agents,
pubmed-meshheading:17150357-Bacillus subtilis,
pubmed-meshheading:17150357-Bacteria,
pubmed-meshheading:17150357-Chelating Agents,
pubmed-meshheading:17150357-Drug Design,
pubmed-meshheading:17150357-Drug Resistance, Multiple, Bacterial,
pubmed-meshheading:17150357-Escherichia coli,
pubmed-meshheading:17150357-Indicators and Reagents,
pubmed-meshheading:17150357-Metals,
pubmed-meshheading:17150357-Microbial Sensitivity Tests,
pubmed-meshheading:17150357-Structure-Activity Relationship
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pubmed:year |
2007
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pubmed:articleTitle |
Design, synthesis, and evaluation of efflux substrate-metal chelator conjugates as potential antimicrobial agents.
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pubmed:affiliation |
Department of Chemistry, Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30302-4098, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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