Linked Life Data

17147010

Source:http://linkedlifedata.com/resource/pubmed/id/17147010

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-12-6
pubmed:abstractText
Inflammatory lung diseases are characterised by increased expression of multiple inflammatory genes that are regulated by proinflammatory transcription factors, such as NF-kappaB. Gene expression is regulated by modifications such as acetylation of core histones through the concerted action of coactivators such as CBP (cAMP-response element binding protein (CREB)-binding protein) which have intrinsic histone acetyltransferase (HAT) activity and are able to recruit other HAT enzymes. Conversely gene repression is mediated via histone deacetylases (HDAC) and other corepressors. In biopsies from asthmatic subjects there is an increase in HAT activity and some reduction in HDAC activity. Both of these changes are partially reversed by corticosteroid therapy. Corticosteroids switch off inflammatory genes in asthma through a combination of a direct inhibition of HAT activity and by the recruitment of HDAC2 to the activated NF-kappaB-stimulated inflammatory gene complex. In chronic obstructive pulmonary disease (COPD), a corticosteroid insensitive disease, there is a reduction in HDAC activity and HDAC2 expression, which may account for the amplified inflammation and resistance to the actions of corticosteroids. The reduction in HDAC2 may be secondary to oxidative and nitrative stress as a result of cigarette smoking and severe inflammation. This may also occur to differing degrees in severe asthma, smoking asthmatic patients and cystic fibrosis. Similar mechanisms may also account for the steroid resistance seen within latent adenovirus infections. The reduction in HDAC activity induced by oxidative stress can be restored by theophylline, acting through specific kinases, which may be able to reverse steroid resistance in COPD and other inflammatory lung diseases. The modulation of HAT/HDAC activity may lead to the development of novel anti-inflammatory approaches to inflammatory lung diseases that are currently difficult to treat.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1541-2555
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
445-55
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:17147010-Acetylation, pubmed-meshheading:17147010-Anti-Inflammatory Agents, pubmed-meshheading:17147010-Asthma, pubmed-meshheading:17147010-Bronchodilator Agents, pubmed-meshheading:17147010-Gene Expression, pubmed-meshheading:17147010-Glucocorticoids, pubmed-meshheading:17147010-Histone Acetyltransferases, pubmed-meshheading:17147010-Histone Deacetylase 1, pubmed-meshheading:17147010-Histone Deacetylase 2, pubmed-meshheading:17147010-Histone Deacetylases, pubmed-meshheading:17147010-Histones, pubmed-meshheading:17147010-Humans, pubmed-meshheading:17147010-Lung Diseases, pubmed-meshheading:17147010-Oxidative Stress, pubmed-meshheading:17147010-Pulmonary Disease, Chronic Obstructive, pubmed-meshheading:17147010-Repressor Proteins, pubmed-meshheading:17147010-Theophylline
pubmed:year
2005
pubmed:articleTitle
Histone deacetylation: an important mechanism in inflammatory lung diseases.
pubmed:affiliation
National Heart and Lung Institute, Imperial College London, UK. ian.adcock@imperial.ac.uk
pubmed:publicationType
Journal Article, Review