rdf:type |
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lifeskim:mentions |
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pubmed:issue |
50
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pubmed:dateCreated |
2006-12-13
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pubmed:abstractText |
A simulation study shows that early protein folding events may be investigated by using a recently developed family of nonlinear infrared techniques that combine the high temporal and spatial resolution of multidimensional spectroscopy with the chirality-specific sensitivity of amide vibrations to structure. We demonstrate how the structural sensitivity of cross-peaks in two-dimensional correlation plots of chiral signals of an alpha helix and a beta hairpin may be used to clearly resolve structural and dynamical details undetectable by one-dimensional techniques (e.g. circular dichroism) and identify structures indistinguishable by NMR.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17146054-10573426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17146054-10890905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17146054-11331745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17146054-11562493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17146054-15102453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17146054-15212548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17146054-15520391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17146054-15758995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17146054-15800619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17146054-15837172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17146054-16040800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17146054-16081697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17146054-16150716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17146054-16438573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17146054-9348659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17146054-9348663
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
18934-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
|
pubmed:year |
2006
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pubmed:articleTitle |
Two-dimensional vibrational optical probes for peptide fast folding investigation.
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pubmed:affiliation |
Department of Chemistry, University of California, Irvine, CA 92697, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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