rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
23
|
pubmed:dateCreated |
2006-12-5
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pubmed:abstractText |
CD52 is a GPI-linked glycoprotein expressed by B cells, T cells, monocytes, and macrophages. The humanized monoclonal antibody alemtuzumab (CAMPATH-1H) is specific for CD52 and is Food and Drug Administration - approved for the treatment of relapsed or refractory chronic lymphocytic leukemia (CLL). The utility of CAMPATH in the treatment of other hematologic neoplasms has been explored; however, a comprehensive survey of CD52 expression among a broad spectrum of WHO-defined tumor types has not been completed.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, Humanized,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/CD52 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/alemtuzumab
|
pubmed:status |
MEDLINE
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pubmed:month |
Dec
|
pubmed:issn |
1078-0432
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
12
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
7174-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17145843-Acute Disease,
pubmed-meshheading:17145843-Antibodies, Monoclonal,
pubmed-meshheading:17145843-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:17145843-Antibodies, Neoplasm,
pubmed-meshheading:17145843-Antigens, CD,
pubmed-meshheading:17145843-Antigens, Neoplasm,
pubmed-meshheading:17145843-Glycoproteins,
pubmed-meshheading:17145843-Humans,
pubmed-meshheading:17145843-Immunohistochemistry,
pubmed-meshheading:17145843-Leukemia, Myeloid,
pubmed-meshheading:17145843-Lymphoma, B-Cell,
pubmed-meshheading:17145843-Lymphoma, T-Cell,
pubmed-meshheading:17145843-Lymphoproliferative Disorders,
pubmed-meshheading:17145843-Treatment Outcome
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pubmed:year |
2006
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pubmed:articleTitle |
Heterogeneous CD52 expression among hematologic neoplasms: implications for the use of alemtuzumab (CAMPATH-1H).
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pubmed:affiliation |
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
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pubmed:publicationType |
Journal Article
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