| pubmed-article:1714564 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:1714564 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:1714564 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:1714564 | lifeskim:mentions | umls-concept:C0039679 | lld:lifeskim |
| pubmed-article:1714564 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:1714564 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:1714564 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:1714564 | lifeskim:mentions | umls-concept:C0887917 | lld:lifeskim |
| pubmed-article:1714564 | lifeskim:mentions | umls-concept:C0441843 | lld:lifeskim |
| pubmed-article:1714564 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:1714564 | pubmed:dateCreated | 1991-9-18 | lld:pubmed |
| pubmed-article:1714564 | pubmed:abstractText | Two protected derivatives of the ribonucleoside inosine have been prepared to serve as building blocks for phosphoramidite-based synthesis of RNA. Two different synthetic routes address the unusual solubility characteristics of inosine and its derivatives. The final products of the different synthetic pathways, 5'-O-(dimethoxytrityl)-2'-O-(t-butyldimethylsiyl) inosine 3'-O-(beta-cyanoethyldiisopropylamino) phosphoramidite 5a, and O6-p-nitrophenylethyl-5'-O-(dimethoxytrityl)-2'-O-(t-butyldimethylsilyl) inosine 3'-O-(methyldiisopropylamino) phosphoramidite 5b, were chemically incorporated into short oligoribonucleotides which also contained the four standard ribonucleoside bases. The oligomers were chosen to study base-specific interactions between an RNA substrate and an RNA enzyme derived from the Group I Tetrahymena self-splicing intron. The oligomers were shown to be biochemically competent using a trans cleavage assay with the modified Tetrahymena intron. The results confirm the dependence of the catalytic activity on a wobble base pair, rather than a Watson-Crick base pair, in the helix at the 5'-splice site. Furthermore, comparison of guanosine and inosine in a wobble base pair allows one to assess the importance of the guanine 2-amino group for biological activity. The preparation of the inosine phosphoramidites adds to the repertoire of base analogues available for the study of RNA catalysis and RNA-protein interactions. | lld:pubmed |
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| pubmed-article:1714564 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1714564 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1714564 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1714564 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1714564 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1714564 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:1714564 | pubmed:author | pubmed-author:GreenRR | lld:pubmed |
| pubmed-article:1714564 | pubmed:author | pubmed-author:RichAA | lld:pubmed |
| pubmed-article:1714564 | pubmed:author | pubmed-author:SzostakJ WJW | lld:pubmed |
| pubmed-article:1714564 | pubmed:author | pubmed-author:UsmanNN | lld:pubmed |
| pubmed-article:1714564 | pubmed:author | pubmed-author:BennerS ASA | lld:pubmed |
| pubmed-article:1714564 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1714564 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:1714564 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:1714564 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1714564 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1714564 | pubmed:pagination | 4161-6 | lld:pubmed |
| pubmed-article:1714564 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1714564 | pubmed:meshHeading | pubmed-meshheading:1714564-... | lld:pubmed |
| pubmed-article:1714564 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1714564 | pubmed:articleTitle | Synthesis of RNA containing inosine: analysis of the sequence requirements for the 5' splice site of the Tetrahymena group I intron. | lld:pubmed |
| pubmed-article:1714564 | pubmed:affiliation | Department of Molecular Biology, Massachusetts General Hospital, Boston 02114. | lld:pubmed |
| pubmed-article:1714564 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1714564 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1714564 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:1714564 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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