| pubmed-article:17143548 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17143548 | lifeskim:mentions | umls-concept:C1522424 | lld:lifeskim |
| pubmed-article:17143548 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:17143548 | lifeskim:mentions | umls-concept:C1622501 | lld:lifeskim |
| pubmed-article:17143548 | lifeskim:mentions | umls-concept:C0300821 | lld:lifeskim |
| pubmed-article:17143548 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:17143548 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:17143548 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17143548 | pubmed:dateCreated | 2006-12-4 | lld:pubmed |
| pubmed-article:17143548 | pubmed:abstractText | The phosphatidylethanolamine (PE)-binding protein (PEBP) family is an evolutionary conserved group of proteins found in various species with multiple functions. We identified human PE-binding protein 4 (hPEBP4), a novel member of the PEBP family, as an anti-apoptotic molecule. Here we describe the cloning and functional characterization of the mouse homolog of hPEBP4 (mouse PEBP4, mPEBP4). Full-length cDNA of mPEBP4 contains 1048 bp with an open reading frame (ORF) of 729 bp, which is predicted to encode a 242-aa protein. mPEBP4 contains a PE-binding domain, in this case between amino acids 106 and 213. mPEBP4 localizes primarily to endoplasmic reticulum/Golgi apparatus. Interestingly, RT-PCR and in situ hybridization analyses indicate that mPEBP4 is specifically expressed in mouse eye tissue. We demonstrate that mPEBP4 promotes cellular migration and invasion by inhibiting ERK1/2 and JNK activation and up-regulating the expression of COX-2. In addition, mPEBP4 overexpression inhibits Epirubicin-induced cellular apoptosis. Considering that mPEBP4 is specifically expressed in retinal ganglion cells, whether mPEBP4 is an important molecule involved in visual function needs to be further investigated. | lld:pubmed |
| pubmed-article:17143548 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17143548 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17143548 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17143548 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17143548 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17143548 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17143548 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17143548 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17143548 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17143548 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17143548 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17143548 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17143548 | pubmed:issn | 1107-3756 | lld:pubmed |
| pubmed-article:17143548 | pubmed:author | pubmed-author:ChiK WKW | lld:pubmed |
| pubmed-article:17143548 | pubmed:author | pubmed-author:WangJianliJ | lld:pubmed |
| pubmed-article:17143548 | pubmed:author | pubmed-author:LiNanN | lld:pubmed |
| pubmed-article:17143548 | pubmed:author | pubmed-author:LiHongzheH | lld:pubmed |
| pubmed-article:17143548 | pubmed:author | pubmed-author:CaoXuetaoX | lld:pubmed |
| pubmed-article:17143548 | pubmed:author | pubmed-author:QiuJianmingJ | lld:pubmed |
| pubmed-article:17143548 | pubmed:author | pubmed-author:ZhangYuanyuan... | lld:pubmed |
| pubmed-article:17143548 | pubmed:author | pubmed-author:WangXiaojianX | lld:pubmed |
| pubmed-article:17143548 | pubmed:author | pubmed-author:XiangZhenghua... | lld:pubmed |
| pubmed-article:17143548 | pubmed:author | pubmed-author:SunQiaolingQ | lld:pubmed |
| pubmed-article:17143548 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17143548 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:17143548 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17143548 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17143548 | pubmed:pagination | 55-63 | lld:pubmed |
| pubmed-article:17143548 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:17143548 | pubmed:meshHeading | pubmed-meshheading:17143548... | lld:pubmed |
| pubmed-article:17143548 | pubmed:meshHeading | pubmed-meshheading:17143548... | lld:pubmed |
| pubmed-article:17143548 | pubmed:meshHeading | pubmed-meshheading:17143548... | lld:pubmed |
| pubmed-article:17143548 | pubmed:meshHeading | pubmed-meshheading:17143548... | lld:pubmed |
| pubmed-article:17143548 | pubmed:meshHeading | pubmed-meshheading:17143548... | lld:pubmed |
| pubmed-article:17143548 | pubmed:meshHeading | pubmed-meshheading:17143548... | lld:pubmed |
| pubmed-article:17143548 | pubmed:meshHeading | pubmed-meshheading:17143548... | lld:pubmed |
| pubmed-article:17143548 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17143548 | pubmed:articleTitle | Promotion of cellular migration and apoptosis resistance by a mouse eye-specific phosphatidylethanolamine-binding protein. | lld:pubmed |
| pubmed-article:17143548 | pubmed:affiliation | Institute of Immunology, Zhejiang University, Hangzhou 310031, PR China. | lld:pubmed |
| pubmed-article:17143548 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17143548 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:73523 | entrezgene:pubmed | pubmed-article:17143548 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17143548 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17143548 | lld:pubmed |
